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| [[Image:1qq2.png|left|200px|thumb|Crystal Structure of Peroxiredoxin ([[1qq2]])]]
| | <StructureSection load='1qq2' size='350' side='right' scene='43/433646/Cv/2' caption='Typical 2-cys peroxiredoxin dimer complex with Cl- ions [[1qq2]]'> |
| {{STRUCTURE_1qq2| PDB=1qq2 | SIZE=400| SCENE= |right|CAPTION=Peroxiredoxin dimer complex with Cl- ions [[1qq2]]}}
| | == Function == |
| | [[Peroxiredoxin]] (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid hyper oxide forming a Cys-SOH intermediate. A second Cys residue resolves the intermediate to a protein disulfide bond. The Prxs are divided into 3 types according to their intermediate resolving mechanism: '''typical 2-Cysteine Prx''' in which the Cys-Cys bond is formed between two subunits, '''atypical 2-Cys Prx''' in which the bond is formed within one subunit and '''1-Cysteine Prx''' which uses a single Cys residue for the catalysis. '''Prx Q''' is the plant homolog of [[Bacterioferritin comigratory protein]]. |
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| | '''Typical 2-Cys Prx'''<br /> |
| | * '''Prx 1''' interacts with signaling molecules<ref>PMID:19923889</ref>. |
| | * '''Prx 2''' is essential for sustaining erythrocyte life span<ref>PMID:18479207</ref>. |
| | * '''Prx 3''' is mitochondria-specific.<ref>PMID:15280382</ref>. |
| | * '''Prx 4''' localizes to the cytoplasm and regulates the activation of NF-κB<ref>PMID:25656995</ref>. |
| | '''Atypical 2-Cys Prx'''<br /> |
| | * '''Prx 5''' protects from mitochondrial DNA damage induced by H<sub>2</sub>O<sub>2</sub><ref>PMID:15848167</ref>. |
| | '''1-Cys Prx'''<br /> |
| | * '''Prx 6''' reduces peroxidized membrane phospholipids<ref>PMID:20919932</ref>. |
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| | == Relevance == |
| | Prx are over expressed in cancer tissue<ref>PMID:11497302</ref>. Prx 4 mediates osteoclast activation in cancer cells<ref>PMID:25779674</ref>. |
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| | == Structural highlights == |
| | In the typical 2-cysteine Prx the <scene name='43/433646/Cv/5'>Cys-Cys bond is formed between two subunits</scene><ref>PMID:10535922</ref>. <scene name='43/433646/Cv/6'>Cl coordination site</scene>. Water molecules is shown as red sphere. |
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| [[Peroxiredoxin]] (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue. The images at the left and at the right correspond to one representative Prx, ''i.e.'' the crystal structure of Peroxiredoxin from rat ([[1qq2]]).
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| == 3D Structures of Peroxiredoxin == | | == 3D Structures of Peroxiredoxin == |
| | [[Peroxiredoxin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
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| [[1qq2]] – 2Cys-Prx – rat<br />
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| [[2c0d]] – Pf2Cys-Prx – ''Plasmodium falciparum''<br />
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| [[1xiy]] – Pf1Cys-Prx<br />
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| [[1xcc]], [[2h01]], [[3tb2]] - 1Cys-Prx – ''Plasmodium yoelii''<br />
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| [[2i81]] - 2Cys-Prx – ''Plasmodium vivax''<br />
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| [[1qmv]] - h2Cys-Prx – human<br />
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| [[2a4v]] – yPrx dot5 C-terminal (mutant) – yeast<br />
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| [[3cmi]] – yPrx hyr1<br />
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| [[4g2e]] – Prx – ''Sulfolobus tokodaii''<br />
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| [[3sbc]] – yPrx Tsa1 (mutant)<br />
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| [[1uul]] - 2Cys-Prx – ''Trypanosoma cruzi''<br />
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| [[1we0]] – Prx – ''Amphibacillus xylanus''<br />
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| [[2cv4]], [[2cx3]], [[2cx4]] – Prx – ''Aeropyrum pernix''<br />
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| [[3drn]] – SsPrx – ''Sulfolobus solfataricus''<br />
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| [[3hjp]] – SsPrx (mutant)<br />
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| [[3ixr]] – Prx PRXQ (mutant) – ''Xylella fastidiosa''<br />
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| ===Peroxiredoxin 1===
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| [[2rii]], [[3hy2]] – hPrx 1 (mutant)+sulfiredoxin 1<br />
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| [[2z9s]] – Prx 1 (mutant) - rat<br />
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| [[4kw6]], [[4fh8]] – Prx 1 – Ancylostoma ceylanicum<br />
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| ===Peroxiredoxin 2===
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| [[1tp9]] – Prx II – ''Populus trichocarpa''<br />
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| [[2pwj]] – Prx II – garden pea<br />
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| [[4dsq]], [[4dsr]], [[4h86]] – yPrx II<br />
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| [[4dss]] – yPrx II (mutant) + thioredoxin II<br />
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| ===Peroxiredoxin 3===
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| [[1zye]] – Prx III (mutant) – bovine<br />
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| ===Peroxiredoxin 4===
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| [[3tjf]], [[3tjg]], [[3tjj]], [[3tjk]], [[3tkr]] - hPrx 4 (mutant)<br />
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| [[3qpm]] – Prx 4 – ''Larimichtys crocea''<br />
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| [[2pn8]], [[3tjb]], [[3tkp]], [[3tkq]], [[3tks]] – hPrx 4<br />
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| ===Peroxiredoxin 5===
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| [[1urm]] – hPrx 5 (mutant) – human<br />
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| [[2vl2]], [[2vl3]], [[2vl9]], [[1h4o]], [[1hd2]], [[1oc3]] – hPrx 5<br />
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| [[3mng]] – hPrx 5+DTT<br />
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| [[2wfc]] – lPrx 5 - lugworm<br />
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| [[2xhf]] – Prx 5 – ''Alvinella pompejana''<br />
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| ===Peroxiredoxin 6===
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| [[2v2g]] – lPrx 6 <br />
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| [[2v32]], [[2v41]] – lPrx 6 (mutant)<br />
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| | == References == |
| | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |