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| == Function == | | == Function == |
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| '''Epoxide hydrolase''' (EH) converts epoxides to trans-dihydrodiols which are excreted from the body. Thus, EH acts as a detoxification agent. Epoxides are formed from degradation of aromatic compounds<ref>PMID:18585390</ref>.<br /> '''Bifunctional EH 2''' or '''soluble EH''' (SEH) is a bifunctional enzyme with the C-terminal domain having EH activity and the N-terminal domain having lipid phosphatase activity.<br /> '''Limonene-1,2-epoxide hydrolase''' catalyzes the conversion of limonene-1,2-epoxide to limonene-1,2-diol<ref>PMID:12773375</ref> . | | '''Epoxide hydrolase''' (EH) converts epoxides to trans-dihydrodiols which are excreted from the body. Thus, EH acts as a detoxification agent. Epoxides are formed from degradation of aromatic compounds<ref>PMID:18585390</ref>.<br /> '''Bifunctional EH 2''' or '''soluble EH''' (SEH) is a bifunctional enzyme with the C-terminal domain having EH activity and the N-terminal domain having lipid phosphatase activity.<br /> '''Limonene-1,2-epoxide hydrolase''' catalyzes the conversion of limonene-1,2-epoxide to limonene-1,2-diol<ref>PMID:12773375</ref> . For details see [[limonene-1,2-epoxide hydrolase]]. |
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| == Disease == | | == Disease == |
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| == Structural highlights == | | == Structural highlights == |
| <scene name='70/708145/Cv/2'>Biological assembly of Human soluble epoxide hydrolase is dimer</scene>. | | <scene name='70/708145/Cv/6'>Biological assembly of Human soluble epoxide hydrolase is dimer</scene>. |
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| <scene name='70/708145/Cv/5'>Inhibitor binding site</scene> (PDB code [[5alf]]).<ref>PMID:25931264</ref> | | <scene name='70/708145/Cv/7'>Inhibitor binding site</scene> (PDB code [[5alf]]).<ref>PMID:25931264</ref> |
| </StructureSection>
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| == 3D Structures of epoxide hydrolase== | | == 3D Structures of epoxide hydrolase== |
| | [[Epoxide hydrolase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Epoxide hydrolase
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| **[[2e3j]] – EH B – ''Mycobacterium tuberculosis''<br />
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| **[[1qo7]], [[3g02]] – AnEH (mutant) – ''Aspergillus niger''<br />
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| **[[2cjp]] – pEH I – potato<br />
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| **[[3cxu]], [[4ufn]], [[4ufo]], [[4ufp]], [[4uhb]], [[4y9s]] – pEH (mutant) <br />
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| **[[4i19]], [[4qa9]], [[4f4z]] – EH – ''Streptomyces carzinostaticus''<br />
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| *Soluble epoxide hydrolase
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| **[[1s8o]], [[3i1y]], [[3i28]], [[3koo]], [[5ahx]], [[5fp0]] – hSEH – human<br />
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| **[[1cqz]] – mSEH – mouse<br />
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| **[[4nzz]] – BmSEH – ''Bacillus megaterium''<br />
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| **[[4inz]] – BmSEH (mutant) <br />
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| **[[1ehy]] – SEH – ''Agrobacterium tumefaciens''<br />
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| *Epoxide hydrolase complex with inhibitor
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| **[[3g0i]] – AnEH + valpromide<br />
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| **[[3rga]] – SlEH + oxazolidinone inhibitor – ''Streptomyces lasaliensis''<br />
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| **[[4rzm]] – SlEH + lasalocid A<br />
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| *Soluble epoxide hydrolase complex with inhibitor
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| **[[1vj5]], [[1zd2]], [[1zd3]], [[1zd4]], [[1zd5]], [[3wk4]], [[4c4x]], [[4c4y]], [[4c4z]], [[5ai5]], [[5akz]], [[5ali]] – hSEH + urea derivative inhibitor<br />
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| **[[1cr6]], [[1ek1]], [[1ek2]] – mSEH + urea derivative inhibitor<br />
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| **[[3otq]], [[3wk7]], [[4y2j]], [[4y2s]], [[4y2v]], [[5ak4]], [[5akh]], [[5aki]], [[5alk]], [[5alq]], [[5alv]], [[5aly]] – hSEH + pyrazole inhibitor<br />
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| **[[5akj]], [[5alf]], [[5als]] – hSEH + imidazole inhibitor<br />
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| **[[5akk]], [[5ald]], [[5aln]], [[5alo]], [[5alw]], [[5am4]] – hSEH + indolone inhibitor<br />
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| **[[5akx]], [[5aky]] – hSEH + indazole inhibitor<br />
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| **[[3wk5]], [[3wk6]], [[3wk8]], [[3wk9]], [[3wkc]], [[5ai8]], [[5aic]], [[5akg]], [[5alg]] – hSEH + thiazole derivative inhibitor<br />
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| **[[3ans]], [[3ant]] – hSEH + synthetic inhibitor<br />
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| **[[3pdc]], [[5ale]] – hSEH catalytic domain + benzoxazole inhibitor<br />
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| **[[4jnc]], [[5alx]] – hSEH catalytic domain + carboxamide inhibitor<br />
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| **[[4x6x]], [[4x6y]] – hSEH catalytic domain + cyclopropane inhibitor<br />
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| **[[4hai]], [[3wka]], [[4ocz]], [[4od0]], [[5ake]], [[5alh]], [[5am1]] – hSEH + piperidine derivative inhibitor<br />
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| **[[4y2p]], [[4y2q]], [[5ai4]], [[5ak5]], [[5ak6]], [[5alt]], [[5am5]] – hSEH + pyridine derivative inhibitor<br />
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| **[[4y2r]] – hSEH + piperazine derivative inhibitor<br />
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| **[[5akl]], [[5alm]], [[5am0]] – hSEH + pyrrolidine derivative inhibitor<br />
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| **[[4y2t]], [[5aib]] – hSEH + benzyloxy derivative inhibitor<br />
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| **[[3wkb]] – hSEH + quinoxaline derivative inhibitor<br />
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| **[[4y2u]], [[5ai6]], [[5alj]], [[5alr]], [[5am2]] – hSEH + quinoline derivative inhibitor<br />
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| **[[4y2x]], [[5alu]], [[5alz]] – hSEH + adamantanyl derivative inhibitor<br />
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| **[[4y2y]] – hSEH + etylmethyamine derivative inhibitor<br />
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| **[[3wkd]], [[5alp]] – hSEH + morpholine derivative inhibitor<br />
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| **[[3wke]], [[5am3]] – hSEH + carbamoyl derivative inhibitor<br />
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| **[[4j03]] – hSEH + fulvestrant<br />
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| **[[5ai0]] – hSEH + phenyl oxadiazolamine inhibitor<br />
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| **[[5ai9]] – hSEH + phenol derivative inhibitor<br />
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| **[[5aia]] – hSEH + benzoate derivative inhibitor<br />
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| **[[5ak3]] – hSEH + indan-amine derivative inhibitor<br />
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| **[[5all]] – hSEH + cyclohexyl methanol inhibitor<br />
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| **[[4o08]] – BmSEH + phenoxy acetamide inhibitor<br />
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| *Soluble epoxide hydrolase complex with product
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| **[[4io0]] – BmSEH + naphthyloxy propane diol<br />
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| *Limonene-1,2-epoxide hydrolase
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| **[[1nww]] – ReEH – ''Rhodococcus erythropolis''<br />
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| **[[4r9k]], [[4r9l]], [[4xbx]], [[4xdw]], [[5cf1]], [[5cf2]], [[5jpp]] – ReEH (mutant)<br />
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| **[[1nu3]] – ReEH + valpromide <br />
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| **[[4xbt]], [[4xdv]], [[5clk]], [[5jpu]] – ReEH (mutant) + cyclohexanediol<br />
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| **[[4xby]], [[5ck6]] – ReEH (mutant) + cyclopentene oxide<br />
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| **[[5aif]], [[5aih]], [[5aii]] – mlEH – metagenomic library<br />
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| **[[5aig]] – mlEH + valpromide <br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |