Isopropylmalate dehydrogenase: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<scene name='49/490899/Cv/ | <scene name='49/490899/Cv/11'>3-isopropylmalate dehydrogenase complex with 3-isopropylmalate, glycerol, NAD, PMSF, Mn+2 and K- ions</scene>. | ||
IMDH active site containing the <scene name='49/490899/Cv/9'>NAD cofactor is located between 2 subunits</scene> and contains the substrate and Mn+2 and K- ions<ref>PMID:25211160</ref>. Water molecules shown as red spheres. | IMDH active site containing the <scene name='49/490899/Cv/9'>NAD cofactor is located between 2 subunits</scene> and contains the substrate and Mn+2 and K- ions<ref>PMID:25211160</ref>. Water molecules shown as red spheres. | ||
<scene name='49/490899/Cv/ | <scene name='49/490899/Cv/12'>MN coordination site</scene>. | ||
<scene name='49/490899/Cv/ | <scene name='49/490899/Cv/13'>K coordination site</scene>. | ||
<scene name='49/490899/Cv/ | <scene name='49/490899/Cv/14'>3-isopropylmalate binding site</scene>. | ||
<scene name='49/490899/Cv/ | <scene name='49/490899/Cv/15'>Whole IMDH active site</scene>. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of isopropylmalate dehydrogenase== | ==3D structures of isopropylmalate dehydrogenase== | ||
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**[[4y1p]] - IMDH + 3IPM + Mg – ''Sulfolobus acidarius''<br /> | **[[4y1p]] - IMDH + 3IPM + Mg – ''Sulfolobus acidarius''<br /> | ||
**[[5j32]] - AtIMDH + 3IPM + Mg<br /> | **[[5j32]] - AtIMDH + 3IPM + Mg<br /> | ||
**[[6xxy]] - IMDH (mutant) + NAD + isobutenyl oxalylhydroxamate – ''Haemophilus influenzae''<BR /> | |||
}} | }} | ||