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Glycolate oxidase: Difference between revisions

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<StructureSection load='' size='350' side='right' caption='Human glycolate oxidase 1 complex with glyoxylate and FMN (PDB entry [[2rdu]])' scene='48/486364/Cv/1'>
<StructureSection load='' size='350' side='right' caption='Human glycolate oxidase 1 complex with glyoxylate and FMN (PDB entry [[2rdu]])' scene='48/486364/Cv/1'>
== Function ==
== Function ==
'''Glycolate oxidase''' (GOX) catalyzes the conversion of (S)-2-hydroxy acid and molecular oxygen to 2-oxo acid and hydrogen peroxide.  In higher plants, GOX catalyzes the oxidation of glycolate to glyoxylate.  GOX is part of the glyoxylate and dicarboxylate metabolism and uses FMN as a cofactor.  GOX catalyzes the first step in the utilization of glycolate as the sole source of carbon<ref>PMID:22286136</ref>.   
'''Glycolate oxidase''' (GOX) or '''hydroxyacid oxidase''' catalyzes the conversion of (S)-2-hydroxy acid and molecular oxygen to 2-oxo acid and hydrogen peroxide.  In higher plants, GOX catalyzes the oxidation of glycolate to glyoxylate.  GOX is part of the glyoxylate and dicarboxylate metabolism and uses FMN as a cofactor.  GOX catalyzes the first step in the utilization of glycolate as the sole source of carbon<ref>PMID:22286136</ref>.   


== Disease ==
== Disease ==
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{{Template:ColorKey_Turn}}
{{Template:ColorKey_Turn}}
) of an α-hydroxy acid oxidase and its <scene name='48/486364/Cv/9'>active site contains the cofactor FMN</scene><ref>PMID:18215067</ref>. Water molecules are shown as red spheres.  
) of an α-hydroxy acid oxidase and its <scene name='48/486364/Cv/9'>active site contains the cofactor FMN</scene><ref>PMID:18215067</ref>. Water molecules are shown as red spheres.  
</StructureSection>
 
==3D structures of glycolate oxidase==
==3D structures of glycolate oxidase==
[[Glycolate oxidase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Glycolate oxidase
 
**[[1gyl]] – sGOX – spinach<br />
**[[2nzl]] – hGOX1 – human<br />
**[[2yvs]] – GOX GLCE subunit – ''Thermus thermophilus''<br />
**[[1tb3]] – rGOX3 – rat
 
*Glycolate oxidase complex


**[[1al8]], [[1al7]] – sGOX + inhibitor<br />
**[[2rdu]] – hGOX1 + glyoxylate<br />
**[[2rdw]] – hGOX1 + sulfate<br />
**[[2w0u]], [[2rdt]] – hGOX1 + inhibitor<br />
**[[3sgz]] – rGOX2 + inhibitor<br />
**[[3giy]] – GOX1/(S)-mandelate dehydrogenase + MES – ''Pseudomonas putida''
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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