Diphthine synthase: Difference between revisions
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<StructureSection load='2owu' size=' | <StructureSection load='2owu' size='450' side='right' scene='52/525183/Cv/1' caption='Diphthine synthase complex with S-adenosyl-L-homocysteine (SAH) and Na+ ion [[2owu]]'> | ||
'''Diphthine synthase''' (DPS) is a S-adenosyl-L-methionine (SAM)-dependent methyltransferase. DPS catalyzes the trimethylation of a specific histidine residue in elongation factor 2 forming a diphthine and producing S-adenosyl-L-homocysteine (SAH). DPS participates in the diphthamide biosynthesis.<ref>PMID:20873788</ref> | '''Diphthine synthase''' (DPS) is a S-adenosyl-L-methionine (SAM)-dependent methyltransferase. DPS catalyzes the trimethylation of a specific histidine residue in elongation factor 2 forming a diphthine and producing S-adenosyl-L-homocysteine (SAH). DPS participates in the diphthamide biosynthesis.<ref>PMID:20873788</ref> | ||
<scene name='52/525183/Cv/5'>SAH binding site</scene>. | |||
<scene name='52/525183/Cv/6'>Na coordination site</scene> ([[2owu]]), water molecules shown as red spheres. | |||
</StructureSection> | </StructureSection> | ||
==3D structures of diphthine synthase== | ==3D structures of diphthine synthase== | ||
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[[2dsg]], [[2dsh]], [[2dsi]], [[2hr8]], [[2dv3]], [[2dv4]], [[2dv5]], [[2dv7]], [[2dxv]], [[2dxw]], [[2dxx]], [[2e07]], [[2e08]], [[2e15]], [[2e16]], [[2e17]], [[2e4n]], [[2e4r]], [[2e7r]], [[2ed3]], [[2ed5]], [[2eeq]], [[2owf]], [[2owg]], [[2owk]], [[2owu]], [[2owv]], [[2egb]], [[2z6r]], [[2egl]], [[2egs]], [[2eh2]], [[2eh4]], [[2eh5]], [[2ehc]], [[2ehl]], [[2ejj]], [[2ejk]], [[2p5c]], [[2p5f]], [[2p6d]], [[2p6i]], [[2p6k]], [[2ejz]], [[2ek2]], [[2ek3]], [[2ek4]], [[2ek7]], [[2eka]], [[2p6l]], [[2p9d]], [[2el0]], [[2el1]], [[2el2]], [[2el3]], [[2eld]], [[2ele]], [[2emr]], [[2emu]], [[2en5]], [[2eni]], [[2pb4]], [[2pb5]], [[2pb6]], [[2pca]], [[2pcg]], [[2pch]], [[2pci]], [[2pck]], [[2pcm]] – PhDPS (mutant) + SAH – ''Pyrococcus horikoshii''<br /> | [[2dsg]], [[2dsh]], [[2dsi]], [[2hr8]], [[2dv3]], [[2dv4]], [[2dv5]], [[2dv7]], [[2dxv]], [[2dxw]], [[2dxx]], [[2e07]], [[2e08]], [[2e15]], [[2e16]], [[2e17]], [[2e4n]], [[2e4r]], [[2e7r]], [[2ed3]], [[2ed5]], [[2eeq]], [[2owf]], [[2owg]], [[2owk]], [[2owu]], [[2owv]], [[2egb]], [[2z6r]], [[2egl]], [[2egs]], [[2eh2]], [[2eh4]], [[2eh5]], [[2ehc]], [[2ehl]], [[2ejj]], [[2ejk]], [[2p5c]], [[2p5f]], [[2p6d]], [[2p6i]], [[2p6k]], [[2ejz]], [[2ek2]], [[2ek3]], [[2ek4]], [[2ek7]], [[2eka]], [[2p6l]], [[2p9d]], [[2el0]], [[2el1]], [[2el2]], [[2el3]], [[2eld]], [[2ele]], [[2emr]], [[2emu]], [[2en5]], [[2eni]], [[2pb4]], [[2pb5]], [[2pb6]], [[2pca]], [[2pcg]], [[2pch]], [[2pci]], [[2pck]], [[2pcm]] – PhDPS (mutant) + SAH – ''Pyrococcus horikoshii''<br /> | ||
[[1vce]] - PhDPS + SAH<br /> | [[1vce]] - PhDPS + SAH<br /> | ||
[[3i4t]] - | [[3i4t]] - DPS (mutant) – ''Entamoeba histolytica''<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||