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==Structure of the Mtr complex== | ==Structure of the Mtr complex== | ||
<StructureSection load='6r2q' size='340' side='right'caption='[[6r2q]]' scene=''> | <StructureSection load='6r2q' size='340' side='right'caption='[[6r2q]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R2Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R2Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[6r2q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Shewanella_baltica Shewanella baltica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R2Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R2Q FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r2q OCA], [http://pdbe.org/6r2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r2q RCSB], [http://www.ebi.ac.uk/pdbsum/6r2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r2q ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qyc|6qyc]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r2q OCA], [http://pdbe.org/6r2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r2q RCSB], [http://www.ebi.ac.uk/pdbsum/6r2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r2q ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A growing number of bacteria are recognized to conduct electrons across their cell envelope, and yet molecular details of the mechanisms supporting this process remain unknown. Here, we report the atomic structure of an outer membrane spanning protein complex, MtrAB, that is representative of a protein family known to transport electrons between the interior and exterior environments of phylogenetically and metabolically diverse microorganisms. The structure is revealed as a naturally insulated biomolecular wire possessing a 10-heme cytochrome, MtrA, insulated from the membrane lipidic environment by embedding within a 26 strand beta-barrel formed by MtrB. MtrAB forms an intimate connection with an extracellular 10-heme cytochrome, MtrC, which presents its hemes across a large surface area for electrical contact with extracellular redox partners, including transition metals and electrodes. | |||
The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire.,Edwards MJ, White GF, Butt JN, Richardson DJ, Clarke TA Cell. 2020 Apr 8. pii: S0092-8674(20)30325-1. doi: 10.1016/j.cell.2020.03.032. PMID:32289252<ref>PMID:32289252</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6r2q" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Clarke | [[Category: Shewanella baltica]] | ||
[[Category: Edwards | [[Category: Clarke, T A]] | ||
[[Category: Edwards, M J]] | |||
[[Category: Cytochrome]] | |||
[[Category: Electron transport]] | |||
[[Category: Greek key]] | |||
[[Category: Membrane protein]] | |||
[[Category: Multiheme]] | |||
Latest revision as of 08:51, 13 May 2020
Structure of the Mtr complexStructure of the Mtr complex
Structural highlights
Publication Abstract from PubMedA growing number of bacteria are recognized to conduct electrons across their cell envelope, and yet molecular details of the mechanisms supporting this process remain unknown. Here, we report the atomic structure of an outer membrane spanning protein complex, MtrAB, that is representative of a protein family known to transport electrons between the interior and exterior environments of phylogenetically and metabolically diverse microorganisms. The structure is revealed as a naturally insulated biomolecular wire possessing a 10-heme cytochrome, MtrA, insulated from the membrane lipidic environment by embedding within a 26 strand beta-barrel formed by MtrB. MtrAB forms an intimate connection with an extracellular 10-heme cytochrome, MtrC, which presents its hemes across a large surface area for electrical contact with extracellular redox partners, including transition metals and electrodes. The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire.,Edwards MJ, White GF, Butt JN, Richardson DJ, Clarke TA Cell. 2020 Apr 8. pii: S0092-8674(20)30325-1. doi: 10.1016/j.cell.2020.03.032. PMID:32289252[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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