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<StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (PDB entry [[3fzf]])' scene='56/568986/Cv/1'>
<StructureSection load='' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (magenta) and ATP (PDB entry [[3fzf]])' scene='56/568986/Cv/1'>


== Function ==
== Function ==
      
      
The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') perform diverse functions. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. <ref>PMID:18264803</ref>
The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') or '''BAG-family molecular chaperone protein''' perform diverse functions. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. <ref>PMID:18264803</ref>


== Structural highlights ==
== Structural highlights ==


BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.
BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.
</StructureSection>


==3D structures of BAG family proteins==
==3D structures of BAG family proteins==
[[BAG family proteins 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*'''BAG-1'''
 
**[[1i6z]] – mBAG-1 BAG domain - mouse<br />
**[[2lwp]] – mBAG-1 BAG domain - NMR<br />
**[[1t7s]] – BAG-1 BAG domain – ''Caenorhabditis elegans''<br />
**[[4hwc]] – AtBAG-1 BAG domain – ''Arabidopsis thaliana''<br />
**[[1wxv]] – hBAG-1 BAG domain – human - NMR<br />
 
*''BAG-1 complex with HSC70''
 
**[[3fzf]] – hBAG-1 BAG domain + HSC70 ATPase domain + ATP<br />
**[[3fzh]], [[3fzk]],  [[3fzl]], [[3fzm]], [[3ldq]], [[3m3z]] – hBAG-1 BAG domain + HSC70 ATPase domain + inhibitor<br />
**[[4hwi]] – AtBAG-1 BAG domain + HSC70 ATPase domain <br />
**[[1hx1]] – BAG-1 BAG domain + HSC70 ATPase domain - bovine<br />
 
*'''BAG-2'''
 
**[[3d0t]] – mBAG-2 BAG domain <br />
 
*''BAG-2 complex with HSC70''
 
**[[3cqx]] – mBAG-2 BAG domain + HSC70 ATPase domain <br />
 
*'''BAG-4'''
 
**[[1m62]], [[1m7k]] – hBAG-4 BAG domain - NMR<br />
 
*'''BAG-5'''
 
**[[1ugo]] – mBAG-5 BAG domain - NMR<br />
**[[2d9d]] – hBAG-5 BAG domain - NMR<br />
 
*''BAG-5 complex with HSC70''
 
**[[3a8y]] – hBAG-5 BAG domain + HSC70 ATPase domain <br />
 
*'''BAG-6'''


**[[4eew]] – hBAG-6 UBL domain <br />
**[[4wwr]], [[4x86]] – hBAG-6 + ubiquitin-like protein 4A <br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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