BAG protein: Difference between revisions

Latest revision as of 11:45, 2 May 2020

Function

The BAG family proteins (Bcl-2 associated athanogenes) or BAG-family molecular chaperone protein perform diverse functions. BAG-1, BAG-2, BAG-4, BAG-5 or BAG family molecular chaperone regulator inhibit the chaperone function of HSC70 and have anti-apoptotic function. ^[1]

Structural highlights

BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.

3D structures of BAG family proteins

BAG family proteins 3D structures

Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (magenta) and ATP (PDB entry 3fzf)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Kabbage M, Dickman MB. The BAG proteins: a ubiquitous family of chaperone regulators. Cell Mol Life Sci. 2008 May;65(9):1390-402. doi: 10.1007/s00018-008-7535-2. PMID:18264803 doi:http://dx.doi.org/10.1007/s00018-008-7535-2

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Kabbage M, Dickman MB. The BAG proteins: a ubiquitous family of chaperone regulators. Cell Mol Life Sci. 2008 May;65(9):1390-402. doi: 10.1007/s00018-008-7535-2. PMID:18264803 doi:http://dx.doi.org/10.1007/s00018-008-7535-2

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@@ Line 1: / Line 1: @@
-<StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (PDB entry [[3fzf]])' scene=''>
+<StructureSection load='' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (magenta) and ATP (PDB entry [[3fzf]])' scene='56/568986/Cv/1'>
+== Function ==
-The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') perform diverse functions.  They contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.  '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function.
+The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') or '''BAG-family molecular chaperone protein''' perform diverse functions. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. <ref>PMID:18264803</ref>
-==3D structures of BAG family proteins==
+== Structural highlights ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.
-'''BAG-1'''
+==3D structures of BAG family proteins==
+[[BAG family proteins 3D structures]]
-[[1i6z]] – mBAG-1 BAG domain - mouse<br />
-[[2lwp]] – mBAG-1 BAG domain - NMR<br />
-[[1t7s]] – BAG-1 BAG domain – Caenorhabditis elegans<br />
-[[4hwc]] – AtBAG-1 BAG domain – Arabidopsis thaliana<br />
-[[1wxv]] – hBAG-1 BAG domain – human - NMR<br />
-'''BAG-1 complex with HSC70'''
-[[3fzf]] – hBAG-1 BAG domain + HSC70 ATPase domain + ATP<br />
-[[3fzh]], [[3fzk]],  [[3fzl]], [[3fzm]], [[3ldq]], [[3m3z]] – hBAG-1 BAG domain + HSC70 ATPase domain + inhibitor<br />
-[[4hwi]] – AtBAG-1 BAG domain + HSC70 ATPase domain <br />
-[[1hx1]] – BAG-1 BAG domain + HSC70 ATPase domain - bovine<br />
-'''BAG-2'''
-[[3d0t]] – mBAG-2 BAG domain <br />
-'''BAG-2 complex with HSC70'''
-[[3cqx]] – mBAG-2 BAG domain + HSC70 ATPase domain <br />
-'''BAG-4'''
-[[1m62]], [[1m7k]] – hBAG-4 BAG domain - NMR<br />
-'''BAG-5'''
-[[1ugo]] – mBAG-5 BAG domain - NMR<br />
-[[2d9d]] – hBAG-5 BAG domain - NMR<br />
-'''BAG-5 complex with HSC70'''
-[[3a8y]] – hBAG-5 BAG domain + HSC70 ATPase domain <br />
-'''BAG-6'''
-[[4eew]] – hBAG-6 UBL domain <br />
+</StructureSection>
+== References ==
+<references/>
 [[Category: Topic Page]]