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| <StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (PDB entry [[3fzf]])' scene=''> | | <StructureSection load='' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (magenta) and ATP (PDB entry [[3fzf]])' scene='56/568986/Cv/1'> |
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| | == Function == |
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| The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') perform diverse functions. They contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. | | The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') or '''BAG-family molecular chaperone protein''' perform diverse functions. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. <ref>PMID:18264803</ref> |
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| ==3D structures of BAG family proteins==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | == Structural highlights == |
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| '''BAG-1'''
| | BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved. |
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| [[1i6z]] – mBAG-1 BAG domain - mouse<br />
| | ==3D structures of BAG family proteins== |
| [[2lwp]] – mBAG-1 BAG domain - NMR<br />
| | [[BAG family proteins 3D structures]] |
| [[1t7s]] – BAG-1 BAG domain – Caenorhabditis elegans<br />
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| [[4hwc]] – AtBAG-1 BAG domain – Arabidopsis thaliana<br />
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| [[1wxv]] – hBAG-1 BAG domain – human - NMR<br />
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| '''BAG-1 complex with HSC70'''
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| [[3fzf]] – hBAG-1 BAG domain + HSC70 ATPase domain + ATP<br /> | |
| [[3fzh]], [[3fzk]], [[3fzl]], [[3fzm]], [[3ldq]], [[3m3z]] – hBAG-1 BAG domain + HSC70 ATPase domain + inhibitor<br />
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| [[4hwi]] – AtBAG-1 BAG domain + HSC70 ATPase domain <br />
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| [[1hx1]] – BAG-1 BAG domain + HSC70 ATPase domain - bovine<br />
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| '''BAG-2'''
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| [[3d0t]] – mBAG-2 BAG domain <br />
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| '''BAG-2 complex with HSC70'''
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| [[3cqx]] – mBAG-2 BAG domain + HSC70 ATPase domain <br />
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| '''BAG-4'''
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| [[1m62]], [[1m7k]] – hBAG-4 BAG domain - NMR<br />
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| '''BAG-5'''
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| [[1ugo]] – mBAG-5 BAG domain - NMR<br />
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| [[2d9d]] – hBAG-5 BAG domain - NMR<br />
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| '''BAG-5 complex with HSC70'''
| | </StructureSection> |
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| [[3a8y]] – hBAG-5 BAG domain + HSC70 ATPase domain <br /> | | == References == |
| | <references/> |
| | [[Category: Topic Page]] |