BAG protein: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (magenta) and ATP (PDB entry [[3fzf]])' scene='56/568986/Cv/1'>
-<StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain complex with HSC70 ATPase domain and ATP (PDB entry [[3fzf]])' scene=''>
+== Function ==
-The '''BAG family proteins ('''Bcl-2 associated athanogenes) perform diverse functions.  They contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.  '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function.
+The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') or '''BAG-family molecular chaperone protein''' perform diverse functions. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. <ref>PMID:18264803</ref>
-==3D structures of BAG family proteinsd==
+== Structural highlights ==
-'''BAG-1'''
+BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.
-[[1i6z]] – mBAG-1 BAG domain - mouse<br />
+==3D structures of BAG family proteins==
-[[2lwp]] – mBAG-1 BAG domain - NMR<br />
+[[BAG family proteins 3D structures]]
-[[1t7s]] – BAG-1 BAG domain – Caenorhabditis elegans<br />
-[[4hwc]] – AtBAG-1 BAG domain – Arabidopsis thaliana<br />
-[[1wxv]] – hBAG-1 BAG domain – human - NMR<br />
-'''BAG-1 complex with HSC70'''
+</StructureSection>
-[[3fzf]] – hBAG-1 BAG domain + HSC70 ATPase domain + ATP<br />
+== References ==
-[[3fzh]], [[3fzk]],  [[3fzl]], [[3fzm]], [[3ldq]], [[3m3z]] – hBAG-1 BAG domain + HSC70 ATPase domain + inhibitor<br />
+<references/>
-[[4hwi]] – AtBAG-1 BAG domain + HSC70 ATPase domain <br />
+[[Category: Topic Page]]
-[[1hx1]] – BAG-1 BAG domain + HSC70 ATPase domain - bovine<br />
-'''BAG-2'''
-[[3d0t]] – mBAG-2 BAG domain <br />
-'''BAG-2 complex with HSC70'''
-[[3cqx]] – mBAG-2 BAG domain + HSC70 ATPase domain <br />
-'''BAG-4'''
-[[1m62]], [[1m7k]] – hBAG-4 BAG domain - NMR<br />
-'''BAG-5'''
-[[1ugo]] – mBAG-5 BAG domain - NMR<br />
-[[2d9d]] – hBAG-5 BAG domain - NMR<br />
-'''BAG-5 complex with HSC70'''
-[[3a8y]] – hBAG-5 BAG domain + HSC70 ATPase domain <br />