Sandbox Reserved 1611: Difference between revisions
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{{Sandbox_Reserved_CH462_Biochemistry_II}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_CH462_Biochemistry_II}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
=Multidrug Transporter ABCG2 in ''Homo Sapiens''= | =Multidrug Transporter ABCG2 in ''Homo Sapiens''= | ||
<StructureSection load=' | <StructureSection load='6ffc' size='350' frame='true' side='right' caption='ABCG2 6ffc' scene=’’> | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Introduction == | == Introduction == | ||
== Function == | == Function == | ||
[https://www-sciencedirect-com.ezproxy.butler.edu/science/article/pii/S0304383505003538] | |||
ABCG2 transports a variety of substrates, particularly flat, hydrophobic, and/or polycylic molecules. It is found in different biological membranes, such as the blood-brain barrier (BBB), blood-testis barrier, and the blood-placental barrier. It is thought to help protect those tissues and many others from cytotoxins. In addition to cytotoxin protection, ABCG2 secretes endogenous substrates in the adrenal gland, excretes toxins in the liver and kidneys, and regulates absorption of substrates. | |||
== Disease == | == Disease == | ||
| Line 14: | Line 17: | ||
== Structural highlights == | == Structural highlights == | ||
[[Image:Ligand_Interactions_6ffc.png|400 px|right|thumb|Figure | [[Image:Ligand_Interactions_6ffc.png|400 px|right|thumb|Figure 1]] | ||
[https://www.nature.com/articles/s41594-018-0049-1 Nature_Structural_&_Molecular_Biology_Vol_25] | |||
[https://www.nature.com/articles/s41586-018-0680-3] | |||
Multidrug Transporter ABCG2 is a <scene name='83/832937/Dimer/1'>dimer</scene> that consists of two cavities separated by a <scene name='83/832937/Leucine_plug/4'>leucine plug</scene>. Cavity 1 is a binding pocket open to the cytoplasm and the inner leaflet of the plasma membrane. Its shape is suitable to bind flat, hydrophobic and polycyclic substrates. Many of its amino acids residues form hydrophobic interactions with the bound substrate, as shown in green in '''Figure 1'''. Cavity 2 is located above the leucine plug. It is empty until a <scene name='83/832937/Atp_and_mg_bound_to_abcg2/4'>magnesium ion and ATP</scene> are bound to ABCG2. <scene name='83/832937/Cysteine_disulfide_bridges/5'>inter- and intra-disulfides</scene> promote the release of the substrate from the cavity into the extracellular space. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<ref name="Ransey">PMID:28504306</ref> | |||
<ref name="Jackson">PMID:29610494</ref> | |||
<ref name="Manolaridis">PMID:30405239</ref> | |||
<ref name="Fetsch">PMID:15990223</ref> | |||
<references/> | <references/> | ||
== Student Contributors == | == Student Contributors == | ||
*Shelby Skaggs | *Shelby Skaggs | ||