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| One specific example of sequence homology is that of loop 6 and loop 7 residues, whose structural contributions are discussed above. In a sequence alignment of 133 TIM sequences, two highly conserved motifs are noticed. First, 114 sequences in loop 6 contain the PXW sequence family (where X is I,L or V in 112 sequences or otherwise a T or K). Secondly, loop 7 contains a highly conserved YGGS motif; however, this motif is only found when the N-terminal hinge contains tryptophan. | | One specific example of sequence homology is that of loop 6 and loop 7 residues, whose structural contributions are discussed above. In a sequence alignment of 133 TIM sequences, two highly conserved motifs are noticed. First, 114 sequences in loop 6 contain the PXW sequence family (where X is I,L or V in 112 sequences or otherwise a T or K). Secondly, loop 7 contains a highly conserved YGGS motif; however, this motif is only found when the N-terminal hinge contains tryptophan. |
| </StructureSection>
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| == 3D Structures of triose phosphate isomerase== | | == 3D Structures of triose phosphate isomerase== |
| | [[Triose phosphate isomerase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *TIM
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| **[[8tim]], [[1tim]], [[1tpb]], [[1tpc]], [[1tpw]] – cTIM – chicken<br />
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| **[[1spq]], [[1sq7]], [[1ssd]], [[1ssg]], [[1su5]], [[1sw0]], [[1sw3]], [[1sw7]], [[1tpu]], [[1tpv]], [[4p61]] - cTIM (mutant) <br />
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| **[[1tmh]] – EcTIM/cTIM – ''Escherichia coli''<br />
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| **[[1tre]], [[4k6a]], [[4iot]] - EcTIM<br />
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| **[[1amk]] – LmTIM – ''Leishmania mexicana''<br />
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| **[[1qds]] - LmTIM (mutant) <br />
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| **[[2vom]], [[4pod]], [[4unk]], [[4unl]] – hTIM (mutant) – human<br />
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| **[[1wyi]], [[1hti]], [[2jk2]], [[4br1]], [[4poc]] – hTIM<br />
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| **[[2j27]], [[1kv5]], [[2j24]], [[2v0t]], [[2v2c]], [[2v2d]], [[2v2h]], [[2y6z]], [[2y70]] - TbTIM (mutant) – ''Trypanosoma brucei''<br />
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| **[[1dkw]], [[1ml1]], [[1mss]], [[1tpd]], [[1tpe]], [[1tpf]], [[1trd]], [[2v5l]], [[3tim]] - TbTIM
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| **[[1ci1]], [[1tcd]] - TcTIM – ''Trypanosoma cruzi''<br />
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| **[[4hhp]], [[4jeq]] – TcTIM (mutant)<br />
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| **[[3q37]] – TcTIM/TbTIM<br />
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| **[[1mo0]] – TIM – ''Caenorhabditis elegans''<br />
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| **[[1i45]], [[4ff7]] – yTIM (mutant) – yeast<br />
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| **[[1ypi]], [[3ypi]] - yTIM<br />
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| **[[1m6j]] – TIM – ''Entamoeba histolytica''<br />
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| **[[1r2r]], [[1r2s]], [[1r2t]] – rTIM – rabbit<br />
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| **[[1vga]], [[2vfd]], [[2vff]], [[3psv]], [[3psw]], [[3pwa]], [[3py2]] – PfTIM (mutant) – ''Plasmodium falciparum''<br />
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| **[[1ydv]] - PfTIM<br />
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| **[[1w0m]] – TIM – ''Thermoproteus tenax''<br />
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| **[[2btm]] – GsTIM – ''Geobacillus stearothermophilus''<br />
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| **[[2dp3]], [[3pf3]], [[4bi5]] - GiTIM (mutant) – ''Giardia intestinalis''<br />
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| **[[2h6r]]– TIM – ''Methanocaldococcus jannaschii''<br />
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| **[[2jgq]] – TIM – ''Helicobacter pylori''<br />
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| **[[3gvg]], [[3ta6]] – MtTIM – ''Mycobacterium tuberculosis''<br />
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| **[[3kxq]] – TIM – ''Bartonella henselae''<br />
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| **[[3m9y]], [[3uwy]] – SaTIM – ''Staphylococcus aureus''<br />
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| **[[4g1k]] – TIM – ''Burkholderia thailandensis''<br />
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| **[[4nvt]] – TIM – ''Brucella melitensis''<br />
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| **[[4ohq]] – TIM – ''Arabidopsis thaliana''<br />
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| *TIM binary complexes with phosphoglycolate
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| **[[2ypi]] - yTIM + 2-phosphoglycolate<br />
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| **[[1aw1]] – MmTIM + 2-phosphoglycolate – ''Moritella marina''<br />
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| **[[1btm]] - GsTIM + 2-phosphoglycolate<br />
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| **[[1n55]] - LmTIM (mutant) + 2-phosphoglycolate<br />
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| **[[3pvf]] - PfTIM (mutant) + 2-phosphoglycolate<br />
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| **[[1lyx]], [[1lzo]] - PfTIM + 2-phosphoglycolate<br />
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| **[[4bi7]], [[4bi6]] - GiTIM (mutant) + 2-phosphoglycolate<br />
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| *TIM binary complexes with phosphoglycerate
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| **[[1iih]], [[4tim]], [[5tim]], [[6tim]] - TbTIM + phosphoglycerate<br />
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| **[[1o5x]], [[1woa]], [[2vfe]], [[2vfg]], [[2vfh]], [[2vfi]] - PfTIM (mutant) + 3-phosphoglycerate<br />
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| **[[1m7o]], [[1m7p]] - PfTIM + 3-phosphoglycerate<br />
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| **[[3uwu]], [[3uwv]], [[3uww]], [[3uwz]] - SaTIM + 3-phosphoglycerate
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| *TIM binary complexes with phosphoglycohydroxamate
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| **[[2vxn]] - LmTIM (mutant) + phosphoglycohydroxamate<br />
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| **[[1tph]] – cTIM + phosphoglycohydroxamate<br />
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| **[[3tao]] - MtTIM + phosphoglycohydroxamate<br />
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| **[[7tim]] - yTIM + phosphoglycohydroxamate<br />
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| *Other TIM binary complexes
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| **[[1ag1]] – TbTIM + phosphate<br />
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| **[[1aw2]] – MmTIM + sulfate<br />
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| **[[1hg3]] – TIM + carboxyethylphosphonate – ''Pyrococcus woesei''<br />
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| **[[1if2]] – LmTIM + IPP<br />
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| **[[2y61]], [[2y62]] - LmTIM (mutant) + glycidol phosphate<br />
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| **[[2y63]] - LmTIM (mutant) + hydroxyacetonephosphate<br />
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| **[[1iig]] - TbTIM + 3-phosphonopropionate<br />
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| **[[1tsi]] – TbTIM + phosphonobutanamide<br />
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| **[[1ney]]– yTIM + dihydroxyacetonephosphate<br />
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| **[[1nf0]] – yTIM (mutant) + dihydroxyacetonephosphate<br />
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| **[[1wob]] - PfTIM (mutant) + sulfate<br />
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| **[[1sux]] – TcTIM + sulfonic acid derivative<br />
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| **[[2oma]] – TcTIM + dithiobenzylamine<br />
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| **[[4mva]] – EcTIM + acetyl phosphate<br />
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| **[[4owg]] – rTIM + phosphoenolpyruvate<br />
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| *MonoTIM – stable monomeric variant of TIM
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| **[[2wsq]], [[2wsr]], [[1tti]], [[1ttj]], [[2vek]], [[2vel]], [[2vem]], [[2ven]], [[2x16]], [[2x1r]], [[2x1s]], [[2x1t]], [[2x1u]], [[2x2g]] – TbMonoTIM (mutant) <br />
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| **[[1tri]], [[2vei]] – TbMonoTIM<br />
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| **[[2v5b]] - TcMonoTIM
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| }}
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| == Additional Resources == | | == Additional Resources == |
| *[[Carbohydrate Metabolism]] | | *[[Carbohydrate Metabolism]] |