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| {{STRUCTURE_1jnf| PDB=1jnf | SIZE=400| SCENE= |right|CAPTION=Rabbit transferrin with Fe+3 (light red), carbonate and Cl- (green) ion, [[1jnf]] }}
| | <StructureSection load='' size='350' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'> |
| | == Function == |
| | '''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]]. |
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| '''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues. TF contains two lobes: at the N and C termini. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white albumen. For details see [[Molecular Playground/Transferrin]].
| | == Relevance == |
| | Carbohydrate-deficient TF may help diagnose alcoholic liver disease<ref>PMID:15908327</ref>. |
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| | == Structural highlights == |
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| | TF contains <scene name='48/480879/Cv/7'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>. |
| | *<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>. |
| | *<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>. |
| == 3D Structures of Transferrin == | | == 3D Structures of Transferrin == |
| | [[Transferrin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *'''Transferrin'''
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| **[[1jnf]] – rTF - rabbit<br />
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| **[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />
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| **[[4x1d]] – hTF + Yb+3 <br />
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| **[[4h0w]] – hTF + Fe+3 + Bi+3<br />
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| **[[1suv]] – hTF + TF receptor <br />
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| **[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
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| **[[1h76]] – TF - pig
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| *Transferrin N lobe
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| **[[1tfd]] – rTF N terminal<br />
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| **[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />
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| **[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
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| **[[1ryo]] - hTF N terminal + oxalate
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| *Transferrin C lobe
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| **[[3skp]] – hTF C terminal<br />
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| *'''Apo transferrin'''
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| **[[1bp5]], [[1btj]] - hTF N terminal<br />
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| **[[2hau]], [[2hav]] – hTF (mutant)
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| *'''Ovotransferrin'''
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| **[[1ovt]], [[1n04]] – cOTF + Fe+3 - chicken<br />
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| **[[2d3i]] – cOTF + Al+3<br />
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| **[[1dot]] – dOTF + Fe+3 - duck
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| *Ovotransferrin N lobe
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| **[[1ovb]], [[1gv8]] – dOTF NII domain <br />
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| **[[1gvc]] - dOTF NII domain + nitrilotriacetate<br />
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| **[[1nnt]], [[1nft]], [[1iej]] – cOTF N terminal<br />
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| *'''Apo ovotransferrin'''
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| **[[1aov]] – dOTF<br />
| | == References == |
| **[[1aiv]], [[1ryx]]– cOTF<br />
| | <references/> |
| **[[1tfa]] - cOTF N terminal<br />
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| **[[1iq7]] - cOTF C terminal<br />
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| **[[1lfc]] – OTF residues 17-41 – bovine - NMR
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| }}
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |