Flaps Morph for HIV Protease: Difference between revisions
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''Click the Toggle Animation Button above to '''start''' these animations if needed.'' | ''Click the Toggle Animation Button above to '''start''' these animations if needed.'' | ||
* <scene name='83/836583/Morph/11'>Morph of ribbon/cartoon with</scene> <font color="magenta">'''flap glycines in magenta'''</font> (Gly 40, 48, 49, 51, 52). | * <scene name='83/836583/Morph/11'>Morph of ribbon/cartoon with</scene> <font color="magenta">'''flap glycines in magenta'''</font> (Gly 40, 48, 49, 51, 52). | ||
* <scene name='83/836583/Morph/ | * <scene name='83/836583/Morph/12'>Morph of ribbon/cartoon with flaps highlighted</scene> in <font color="orange">'''orange'''</font>. (Flaps: residues 42-58.) | ||
* <scene name='83/836583/Morph/ | * <scene name='83/836583/Morph/13'>Morph of spacefilling rendition</scene> with flaps highlighted in <font color="orange">'''orange'''</font>. | ||
In the case of mutant [[1tw7]], about 100 water molecules (not shown) reside in the active site, forming a hydrogen-bonded scaffold holding the flaps open<ref name="wide-open" />. | In the case of mutant [[1tw7]], about 100 water molecules (not shown) reside in the active site, forming a hydrogen-bonded scaffold holding the flaps open<ref name="wide-open" />. | ||
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Year | Year | ||
</td><td> | </td><td> | ||
Resolution; Rfree* | [[Resolution]]; [[Rfree|R<sub>free</sub>]]* | ||
</td><td> | </td><td> | ||
Asymm. Unit | [[Asymmetric unit|Asymm. Unit]] | ||
</td><td> | </td><td> | ||
Ile50 dist.† | Ile50 dist.† | ||
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</td><td> | </td><td> | ||
</td></tr></table> | </td></tr></table> | ||
<nowiki>*</nowiki>Rfree is categorized by [[FirstGlance in Jmol]] as A (Average), BTA (Better Than Average), U (Unreliable), WTA (Worse Than Average) at the corresponding resolution. | <nowiki>*</nowiki>[[Rfree|R<sub>free</sub>]] is categorized by [[FirstGlance in Jmol]] as A (Average), BTA (Better Than Average), U (Unreliable), WTA (Worse Than Average) at the corresponding resolution. | ||
<br> | <br> | ||
† Distance between the Ile50 alpha carbons in each chain. These are near the tips of the flaps, and this distance is commonly used in the literature to measure the openness of the flaps. | † Distance between the Ile50 alpha carbons in each chain. These are near the tips of the flaps, and this distance is commonly used in the literature to measure the openness of the flaps. | ||