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<StructureSection load='3ndd' size='400' side='right' caption='Structure of cleaved human serpin A1.  Residues 46-382 (grey), residues 383-418 (green). (PDB entry [[3ndd]])' scene=''>
<StructureSection load='2xn6' size='350' side='right' caption='Structure of cleaved human serpin A7.  Residues 32-380 (cyan), residues 381-415 (salmon) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene='51/517379/Cv/1'>
 
== Function ==
'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br />
'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br />
* Ser E1 is antithrombin. <br />
* Ser C1 is [[Antithrombin]].<br />
* Ser C1 is   antithrombin.<br />
* Ser A5 is protein C inhibitor.<br />
* Ser A5 is protein C inhibitor.<br />
* Ser A6 is a cortisol-binding globulin. <br />
* Ser A6 is [[Corticosteroid-binding globulin]]. <br />
* Ser A8 is angiotensinogen. <br />
* Ser A8 is angiotensinogen. <br />
* Ser A7 is a thyroxine-binding globulin.<br />
* Ser A7 is a thyroxine-binding globulin.<br />
* Ser B1 is leukocyte elastase inhibitor.<br />
* Ser B1 is leukocyte elastase inhibitor<ref>PMID:26701651</ref>.<br />
* Ser B3 is squamos cell carcinoma antigen 1. <br />
* Ser B3 is squamos cell carcinoma antigen 1<ref>PMID:20527027</ref>. <br />
* Ser B5 is Maspin.<br />
* Ser B5 is Maspin<ref>PMID:11309327</ref>.<br />
* Ser crmA is cysteine and serine proteinase inhibitor.<br />
* Ser crmA is cysteine and serine proteinase inhibitor<ref>PMID:9065443</ref>.<br />
* Ser I1 is neuroserpin. <br />
* Ser I1 is neuroserpin. <br />
* Ser A10 is protein Z-related protease inhibitor. <br />
* Ser A10 is protein Z-related protease inhibitor. <br />
* Ser A1 is α-1 antitrypsin. <br />
* Ser A1 is [[Alpha-1-antitrypsin]]. <br />
* Ser A3 is α 1-antichymotrypsin.<br />
* Ser A3 is α 1-antichymotrypsin.<br />
* Ser E1 is plasminogen activator inhibitor 1.   
* Ser E1 is [[Plasminogen activator inhibitor]].   
</StructureSection>
 
==3D structures of serpin==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== Disease ==
{{#tree:id=OrganizedByTopic|openlevels=0|
Mutation in Ser A7 causes partial thyroxine-binding globulin deficiency<ref>PMID:24356794</ref>.  Ser B3 may contribute to tumor cell resistance to anti-neoplastic drugs<ref>PMID:25332258</ref>.  Ser A3 promotes growth of endometrial cancer cells <ref>PMID:24817931</ref>.


*Serpin
==Structural highlights ==
Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres.


**[[1mtp]], [[1sng]] – Ser – ''Thermobifida fusca''
==3D structures of serpin==
[[Serpin 3D structures]]


*Serpin A1 see [[Alpha-1-antitrypsin]]
</StructureSection>
 
*Serpin A3 (α 1-antichymotrypsin)
 
**[[2ach]], [[1as4]], [[3caa]] – hSer-A3<br />
**[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br />
**[[1yxa]] – mSer-A3N - mouse<br />
 
*Serpin A5
 
**[[2ol2]] – hSer-A5<br />
**[[3dy0]] – hSer-A5 + heparin
 
*Serpin A6 see [[Corticosteroid-binding globulin]]
 
*Serpin A7
 
**[[2riv]] – hSer-A7<br />
**[[2riw]] – hSer-A7 + thyroxine<br />
**[[2xn3]] – hSer-A7 + mefenamic acid<br />
**[[2xn5]] – hSer-A7 + furosemide<br />
**[[2xn6]], [[2xn7]] – hSer-A7 + thyroxine-fluoresein
 
*Serpin A8
 
**[[2jp8]] – hSer-A8 – NMR<br />
**[[2wxw]] – hSer-A8<br />
**[[2x0b]] – hSer-A8 + renin<br />
**[[2wxx]], [[2wxy]], [[2wy0]] – Ser-A8 – mouse<br />
**[[2wxz]], [[2wy1]] – rSer-A8
 
*Serpin A10
 
**[[3h5c]], [[3f1s]] – hSer-A10 + vitamin K-dependent protein Z
 
*Serpin A12
 
**[[4if8]] – hSer-A12<br />
 
*Serpin B1 (leukocyte elastase inhibitor)
 
**[[1hle]] – Ser-B1 – horse <br />
**[[4ga7]] – hSer-B1 (mutant) <br />
 
*Serpin B3
 
**[[2zv6]] – hSer-B3
 
*Serpin B5 (Maspin)
 
**[[1xqg]], [[1wz9]], [[1xu8]] - hSer-B5<br />
**[[1xqj]] – hSer-B5 (mutant) <br />
 
*Serpin C1 see [[Antithrombin]]
 
*Ser crmA (ice inhibitor)
 
**[[1c8o]], [[1f0c]] – cvSer-crmA (mutant) – cowpox virus<br />
 
*Serpin E1 see [[Plasminogen activator inhibitor]]
 
*Serpin E2
 
**[[4dy0]] – hSer-E2 + heparin
 
*Serpin I1 (Neuroserpin)
 
**[[3fgq]], [[2f02]], [[3f5n]] – hSer-I1<br />
**[[1jjo]] – mSer-I1<br />
 
*Serpin K
 
**[[1sek]] – ThSer-K – Tobacco hornworm
 
*Serpin 1
 
**[[1k9o]] – ThSer-1 (mutant) + trypsin II<br />
**[[3le2]] – Ser-1 – ''Arabidopsis thaliana''
 
*Serpin 2
 
**[[1m93]] – cvSer-2 <br />
**[[3nda]] – Ser-2 – Sheep tick<br />
**[[3pzf]] – mmSer-2 – malaria mosquito<br />
**[[4ro9]], [[4roa]], [[4rob]], [[4rsq]] – mmSer-2 (mutant)<br />
 
*Ser 4 (Serine protease inhibitor 4)
 
**[[4p0f]], [[4p0o]] – Ser-4 – ''Drosophila melanogaster''<br />


}}
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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