Serpin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='2xn6' size='350' side='right' caption='Structure of cleaved human serpin A7.  Residues 32-380 (cyan), residues 381-415 (salmon) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene='51/517379/Cv/1'>
+== Function ==
+'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br />
+* Ser C1 is [[Antithrombin]].<br />
+* Ser A5 is protein C inhibitor.<br />
+* Ser A6 is [[Corticosteroid-binding globulin]]. <br />
+* Ser A8 is angiotensinogen. <br />
+* Ser A7 is a thyroxine-binding globulin.<br />
+* Ser B1 is leukocyte elastase inhibitor<ref>PMID:26701651</ref>.<br />
+* Ser B3 is squamos cell carcinoma antigen 1<ref>PMID:20527027</ref>. <br />
+* Ser B5 is Maspin<ref>PMID:11309327</ref>.<br />
+* Ser crmA is cysteine and serine proteinase inhibitor<ref>PMID:9065443</ref>.<br />
+* Ser I1 is neuroserpin. <br />
+* Ser A10 is protein Z-related protease inhibitor. <br />
+* Ser A1 is [[Alpha-1-antitrypsin]]. <br />
+* Ser A3 is α 1-antichymotrypsin.<br />
+* Ser E1 is [[Plasminogen activator inhibitor]].
-<StructureSection load='3ndd' size='400' side='right' caption='Structure of human serpin A1 (PDB entry [[3ndd]])' scene=''>
+== Disease ==
+Mutation in Ser A7 causes partial thyroxine-binding globulin deficiency<ref>PMID:24356794</ref>.  Ser B3 may contribute to tumor cell resistance to anti-neoplastic drugs<ref>PMID:25332258</ref>.  Ser A3 promotes growth of endometrial cancer cells <ref>PMID:24817931</ref>.
+==Structural highlights ==
+Ser A7 - a thyrosine-binding globulin - <scene name='51/517379/Cv/3'>binding site contains thyroxin derivative</scene><ref>PMID:21325280</ref>. Water molecules are shown as red spheres.
-'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.  Ser E1 is antithrombin.  Ser C1 is   antithrombin .  Ser A5 is protein C inhibitor.  Ser A6 is a cortisol-binding globulin.  Ser A8 is angiotensinogen.    Ser A7 is a thyroxine-binding globulin.  Ser B3 is squamos cell carcinoma antigen 1.  Ser I1 is neuroserpin.  Ser A10 is protein Z-related protease inhibitor.  Ser A1 is alpha-1 antitrypsin.   Ser E1 is plasminogen activator inhibitor 1.
- ‬
 ==3D structures of serpin==
+[[Serpin 3D structures]]
-===Ser===
+</StructureSection>
-[[1mtp]], [[1sng]] – Ser – ''Thermobifida fusca''
-===Ser A1===
-[[3ndd]], [[3ndf]], [[3ne4]] – hSer-A1 – human<br />
-[[3t1p]] – hSer-A1 (mutant)
-===Ser A5===
-[[2ol2]] – hSer-A5<br />
-[[3dy0]] – hSer-A5 + heparin
-===Ser A6===
-[[2v95]] – rSer-A6 – rat<br />
-[[2vdx]] – hSer-A6 (mutant) <br />
-‪[[2vdx]] – hSer-A6 (mutant) + cortisol‬
-===Ser A7===
-[[2riv]] – hSer-A7<br />
-[[2riw]] – hSer-A7 + thyroxine<br />
-[[2xn3]] – hSer-A7 + mefenamic acid<br />
-[[2xn5]] – hSer-A7 + furosemide<br />
-[[2xn6]], [[2xn7]] – hSer-A7 + thyroxine-fluoresein
-===Ser A8===
-[[2jp8]] – hSer-A8 – NMR<br />
-[[2wxw]] – hSer-A8<br />
-[[2x0b]] – hSer-A8 + renin<br />
-[[2wxx]], [[2wxy]], [[2wy0]] – Ser-A8 – mouse<br />
-[[2wxz]], [[2wy1]] – rSer-A8
-===Ser A10===
-[[3h5c]], [[3f1s]] – hSer-A10 + vitamin K-dependent protein Z
-===Ser B3===
-[[2zv6]] – hSer-B3
-===Ser C1===
-[[Antithrombin]]
-===Ser E1===
-[[Plasminogen activator inhibitor]]
-===Ser E2===
-[[4dy0]] – hSer-E2 + heparin
-===Ser-I1===
-[[3fgq]], [[2f02]], [[3f5n]] – hSer-I1
-===Ser K===
-[[1sek]] – ThSer-K – Tobacco hornworm
-===Ser 1===
-[[1k9o]] – ThSer-1 (mutant) + trypsin II<br />
+== References ==
-[[3le2]] – Ser-1 – ''Arabidopsis thaliana''
+<references/>
+[[Category:Topic Page]]
-===Ser 2===
-[[1m93]] – Ser-2 – Cowpox virus<br />
-[[3nda]] – Ser-2 – Sheep tick<br />
-[[3pzf]] – Ser-2 – malaria mosquito
-===Maspin===
-[[1xqg]], [[1xqj]], [[1wz9]], [[1xu8]] - hMapsin
-</StructureSection>