Tryptophan hydroxylase 1 with bound tryptophan: Difference between revisions
New page: <StructureSection load="3e2t" size="400" color="" frame="true" spin="on" Scene='3e2t/3e2t_overall/2' align="right" caption= > left|300px <!-- The line below this pa... |
No edit summary |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load="3e2t" size="400" color="" frame="true" spin="on" Scene='3e2t/3e2t_overall/2' | <StructureSection load="3e2t" size="400" color="" frame="true" spin="on" Scene='3e2t/3e2t_overall/2' side="right" caption= > | ||
[[Image:3e2t_1.jpg|left|300px]] | [[Image:3e2t_1.jpg|left|300px]] | ||
===The catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan=== | ===The catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan=== | ||
[[Tryptophan hydroxylase]] is an iron and tetrahydrobiopterin dependent monooxygenase which belongs to the enzyme family of | [[Tryptophan hydroxylase]] is an iron and tetrahydrobiopterin dependent monooxygenase which belongs to the enzyme family of aromatic amino acid hydroxylases. | ||
The structure presented here is of the catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan substrate. | The structure presented here is of the catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan substrate. | ||
| Line 37: | Line 30: | ||
== Iron coordination == | == Iron coordination == | ||
The <scene name='User:Michael_Skovbo_Windahl/sandbox/3e2t_iron_coordination/3'>iron is coordinated</scene> by 2 histidines, one glutamate and one imidazole from the solvent. | The <scene name='User:Michael_Skovbo_Windahl/sandbox/3e2t_iron_coordination/3'>iron is coordinated</scene> by 2 histidines, one glutamate and one imidazole from the solvent. | ||
This coordination is called the 2-histidine-1-glutamate facial triad iron coordination and is seen in many mononuclear non-heme iron(II)enzymes<ref>PMID: 15739104</ref>. In this structure Glu317 coordinates the iron in a partial bidentate manner. The more common <scene name='User:Michael_Skovbo_Windahl/sandbox/1mlw_iron_coordination/3'>octahedral iron coordination</scene> (the resting state) for the 2-His-1-Glu iron coordination is seen in the structure of human TPH1 ([[1mlw]]). | This coordination is called the 2-histidine-1-glutamate facial triad iron coordination and is seen in many mononuclear non-heme iron(II)enzymes<ref>PMID: 15739104</ref>. In this structure Glu317 coordinates the iron in a partial bidentate manner. The more common <scene name='User:Michael_Skovbo_Windahl/sandbox/1mlw_iron_coordination/3'>octahedral iron coordination</scene> (the resting state) for the 2-His-1-Glu iron coordination is seen in the structure of human TPH1 ([[1mlw]]). | ||
| Line 47: | Line 40: | ||
<br/> | <br/> | ||
{{ABSTRACT_PUBMED_18937498}} | {{ABSTRACT_PUBMED_18937498}} | ||
</StructureSection> | |||
==About this Structure== | ==About this Structure== | ||
3E2T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2T OCA]. | 3E2T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2T OCA]. | ||
| Line 78: | Line 67: | ||
[[Category: Petersen, C R.]] | [[Category: Petersen, C R.]] | ||
[[Category: Windahl, M S.]] | [[Category: Windahl, M S.]] | ||
<br /> | |||
Created with the participation of [[User:Michael Skovbo Windahl|Michael Skovbo Windahl]], [[User:Eran Hodis|Eran Hodis]], [[User:David Canner|David Canner]]. | |||
