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<StructureSection load='3mx2' size='400' side='right' caption='Nucleoprotein from Lassa virus trimer complex with TTP and Zn+2 ions (grey) [[3mx2]]' scene='46/461363/Cv/2'>
<StructureSection load='' size='350' side='right' caption='Nucleoprotein from Lassa virus trimer complex with TTP and Zn+2 ions (grey) [[3mx2]]' scene='46/461363/Cv/2' pspeed='8'>
 
__TOC__
== Function ==


'''Nucleoproteins''' (NP) are proteins associated with DNA or RNA<ref>PMID:2203758</ref>.  NPs which contain RNA are called '''ribonucleoproteins''' (RNPs).  The NP RNA-recognition motif is named RRM.<br />
'''Nucleoproteins''' (NP) are proteins associated with DNA or RNA<ref>PMID:2203758</ref>.  NPs which contain RNA are called '''ribonucleoproteins''' (RNPs).  The NP RNA-recognition motif is named RRM.<br />
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The '''heterogenous nuclear ribonucleoproteins''' (hnRNP) are RNA-protein complexes which associates with the splicing apparatus and prevent the folding of pre-mRNA<ref>PMID:19099192</ref>. <br />
The '''heterogenous nuclear ribonucleoproteins''' (hnRNP) are RNA-protein complexes which associates with the splicing apparatus and prevent the folding of pre-mRNA<ref>PMID:19099192</ref>. <br />
For details on '''heterogenous nuclear ribonucleoproteins''' see [[HnRNP A1]].<br />
For details on '''heterogenous nuclear ribonucleoproteins''' see [[HnRNP A1]].<br />
For homology model and multiple sequence alignment see [[User:Michael Strong/H1N1/NP]] and [[User:Michael Strong/H1N1/NP/MSA]].
For homology model and multiple sequence alignment see [[User:Michael Strong/H1N1/NP]] and [[User:Michael Strong/H1N1/NP/MSA]].<br />
</StructureSection>
For details on HIV-1 nucleoprotein see [[HIV-1 Nucleocapsid Protein (NC)]].
== 3D Structures of Nucleoprotein ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== Structural highlights ==
{{#tree:id=OrganizedByTopic|openlevels=0|
*<scene name='46/461363/Cv/6'>TTP binding site</scene> in Nucleoprotein from Lassa virus ([[3mx2]]). Water molecules are shown as red spheres.
*<scene name='46/461363/Cv/7'>Zn coordination site</scene>.


*'''Nucleoprotein'''
== 3D Structures of Nucleoprotein ==
[[Nucleoprotein 3D structures]]


**[[3ouo]], [[3ov9]] – NP – Rift valley fever virus<br />
</StructureSection>
**[[3q7b]], [[3q7c]] – LvNP exonuclease domain – Lassa virus<br />
**[[3mwp]], [[3mwt]], [[3r3l]] – LvNP<br />
**[[3pto]] - VvNP – Vesicular stomatitis Indiana virus<br />
**[[2qvj]] – VvNP (mutant)<br />
**[[2k48]] – NP N terminal – Andes virus - NMR<br />
**[[1ssk]] - ScvNP N terminal – SARS coronavirus – NMR<br />
**[[4j3k]] – ScvNP N terminal<br />
**[[2gib]] – ScvNP dimerization domain<br />
**[[2jw8]] - ScvNP dimerization domain – NMR<br />
**[[2ofz]], [[2og3]] - ScvNP RNA-binding domain<br />
**[[3hd4]] – NP N terminal – Murine hepatitis virus<br />
**[[2wfs]], [[2ymn]] – IvNP – Cryo EM – Influenza virus<br />
**[[4dys]], [[4iry]] – IvNP <br />
**[[3zdp]], [[4dyt]] – IvNP (mutant)<br />
**[[2q06]], [[2iqh]], [[3tj0]] – IvNP<br />
**[[2i8b]] – EvNP C terminal – Ebola virus – NMR<br />
**[[3v7o]], [[4qaz]], [[4qb0]] - EvNP C terminal<br />
**[[1yvr]] – XlNP Ro – ''Xenopus laevis''<br />
**[[1wwf]] – MvNP P10 – Moloney murine leukemia virus – NMR<br />
**[[2c86]], [[2gec]] – BvNP N terminal – Avian infectious bronchitis virus<br />
**[[2ca1]], [[2ge7]], [[2ge8]] – BvNP dimerization domain<br />
**[[2btl]], [[2bxx]] – BvNP RRM (mutant)<br />
**[[1n93]], [[1pp1]] – NP P40 – Borna disease virus<br />
**[[4aqf]], [[4aqg]] – NP N – Crimean-Congo hemorrhagic fever virus<br />
**[[4fi5]] – NP N terminal – Hantaan virus<br />
**[[4bgp]] – LcvNP – La crosse virus<br />
**[[4gve]] – NP C terminal – Tacaribe virus<br />
**[[4idu]], [[4idx]] – SvNP – Schmallenberg virus<br />
**[[4k7e]] – NP C terminal – Junin virus<br />
**[[4o6h]] – NP C terminal – Lymphocytic choriomeningitis virus<br />
 
*Nucleoprotein binary complex
 
**[[3mx2]], [[3mx5]] – LvNP + nucleotide<br />
**[[3t5n]], [[3t5q]], [[4fvu]], [[4g9z]], [[4gv3]], [[4gv6]], [[4gv9]] – LvNP + RNA<br />
**[[3ptx]], [[3pu0]], [[3pu1]], [[3pu4]], [[2gic]] – VvNP + RNA<br />
**[[2wyy]] – VvNP + poly U – Cryo EM<br />
**[[3hhw]], [[3pmk]] – VvNP + phosphoprotein<br />
**[[3hhz]] - VvNP + phosphoprotein + RNA<br />
**[[4co6]] - NP + phosphoprotein – Nipah virus<br />
**[[2wj8]], [[2yhm]], [[4bkk]] – NP + RNA – Human respiratory syncytial virus<br />
**[[2i91]], [[1yvp]] – XlNP Ro + RNA <br />
**[[2gtt]] – NP + RNA – Rabies virus<br />
**[[1wwg]], [[1wwd]], [[1wwe]], [[1u6p]] - MvNP P10 + RNA – NMR<br />
**[[3ro5]], [[4dya]], [[4dyb]], [[4dyn]], [[4dyp]], [[3tg6]] – IvNP + ligand<br />
**[[4bbl]] – IvNP + RNA – Cryo EM<br />
**[[3zla]] – BvNP + RNA – Bunyamwera virus<br />
**[[4ijs]] – BvNP (mutant) + RNA <br />
**[[4bhh]] – LcvNP + poly-U<br />
**[[4jng]] – SvNP + RNA <br />
**[[4j1g]], [[4j1j]] – NP + RNA – Leanye virus<br />
**[[4kxj]] – ScvNP N terminal + PJ34 <br />
**[[4li4]], [[4lm7]], [[4lm9]], [[4lmc]] – ScvNP N terminal + nucleotide <br />
**[[4lmt]] – ScvNP N terminal + quinoline derivative <br />
**[[4ypi]] - EvNP + peptide – Cryo EM<br />
 
*'''Ribonucleoprotein'''
 
**[[2lbw]] – yRNP subunit 2 residues 36-156 (mutant) – yeast – NMR<br />
**[[2lbx]] - yRNP subunit 2 residues 36-156 – NMR<br />
**[[4h5l]], [[4csg]] – TvRNP – Toscana virus<br />
**[[4csf]] – TvRNP + RNA<br />
**[[4uft]] – RNP + RNA – Measles virus<br />
 
*'''Small nuclear ribonucleoprotein'''
 
**[[2a3j]], [[1fht]] - h-snRNP U1 A RRM – human - NMR<br />
**[[2u1a]] - h-snRNP U1 A RRM (mutant) – NMR<br />
**[[1dz5]] - h-snRNP U1 A  (mutant) – NMR<br />
**[[1oia]] - h-snRNP U1 A RRM<br />
**[[2l5i]], [[2l5j]] - h-snRNP U1 70kDa residues 131-151 – NMR<br />
**[[2vy4]], [[2vy5]] - h-snRNP U11/U12 – NMR<br />
**[[2cqj]] - h-snRNP U3 S4 domain – NMR<br />
**[[1x4q]] - h-snRNP U4/U6 PWI domain - NMR<br />
**[[2vrd]] - h-snRNP U1 C zinc finger domain - NMR<br />
**[[1b34]] - h-snRNP D1 + h-snRNP D2<br />
**[[1d3b]] - h-snRNP SM D3 SM motif + h-snRNP-associated protein<br />
**[[1khm]] - h-snRNP K C terminal (mutant) – NMR<br />
**[[2k3k]] – Dm-snRNP U1 A RRM1 – ''Drosophila melanogaster'' – NMR<br />
**[[2aym]] - Dm-snRNP U1 A<br />
**[[2b0g]] - Dm-snRNP U1 A RBD2 – NMR<br />
**[[1n9r]], [[1n9s]] – y-snRNP F
 
*Small nuclear ribonucleoprotein binary complex
 
**[[3plu]], [[3plv]] – y-snRNP HINDI domain + ubiquitin-like modifier HUB1<br />
**[[4wzj]] – h-snRNP  U4 core domain<br />
**[[3p49]] - h-snRNP A RRM + glycine riboswitch RNA<br />
**[[3iwn]] - h-snRNP U1 A RRM (mutant) + riboswitch RNA<br />
**[[3pgw]], [[3mum]], [[3mur]], [[3mut]], [[3muv]], [[3egz]] - h-snRNP U1 A + DNA riboswitch<br />
**[[3mxh]], [[3irw]] - h-snRNP U1 A (mutant) + DNA riboswitch<br />
**[[3k0j]], [[1drz]], [[1m5k]], [[1m5o]], [[1m5p]], [[1m5v]], [[1u6b]], [[3ucu]], [[3ucz]], [[3ud3]], [[3ud4]] - h-snRNP U1 A (mutant) + RNA<br />
**[[3bo2]], [[3bo3]], [[3bo4]] - h-snRNP U1 A RRM + RNA<br />
**[[1sj3]], [[1sj4]], [[1sjf]], [[1vbx]], [[1vby]], [[1vbz]], [[1vc0]], [[1vc5]], [[1vc6]], [[1vc7]] - h-snRNP U1 A (mutant) + Hepatitis ribozyme<br />
**[[3r1h]], [[3r1l]] - h-snRNP U1 A (mutant) + ribozyme<br />
**[[1aud]] - h-snRNP U1 A (mutant) + RNA - NMR<br />
**[[3iin]] - h-snRNP U1 A (mutant) + group I intron + DNA<br />
**[[4c4w]] - h-snRNP A RRM 1 + TSKT K-turn motif + ribosomal protein L7AE<br />
**[[3b02]], [[3b03]], [[3b04]] - h-snRNP U1 A RRM1 + group I intron + RNA<br />
**[[1zzn]] - h-snRNP U1 A RRM1 (mutant) + group I intron + RNA<br />
**[[3l3c]], [[3g8s]], [[3g8t]], [[3g96]], [[3g9c]], [[2nz4]] - h-snRNP U1 A (mutant) + GLMS ribozyme + RNA<br />
**[[3hhn]] - h-snRNP U1 A (mutant) + class I ligase ribozyme<br />
**[[2oih]], [[2oj3]] - h-snRNP U1 A + HDV ribozyme<br />
**[[3cul]], [[3cun]] - h-snRNP U1 A (mutant) + aminoacyl-tRNA synthetase ribozyme<br />
**[[3cw1]] - h-snRNP U1 in spliceosome<br />
**[[2ozb]], [[3siu]], [[3siv]] - h-snRNP U4/U6 + NHP2-like protein + RNA<br />
**[[3s6n]], [[4v98]], [[4f7u]] - h-snRNP 8S assembly<br />
**[[4m77]], [[4m78]], [[4m7a]], [[4m7d]] - h-snRNP LSM8 assembly<br />
**[[2bn5]] - Dm-snRNP U1 70kDa + PSI B box – NMR<br />
 
*'''Heterogenous nuclear ribonucleoprotein'''
 
**[[3s01]] – m-hnRNP L RRM3 domain – mouse<br />
**[[3tyt]] - m-hnRNP L<br />
**[[2e5i]] - m-hnRNP L RRM – NMR<br />
**[[2db1]] - m-hnRNP F RRM – NMR<br />
**[[1ha1]], [[1l3k]], [[1up1]] - h-hnRNP A1 RRM<br />
**[[2lyv]] - h-hnRNP A1 RRM 1-2 – NMR<br />
**[[2up1]] - h-hnRNP A1 RRM 1-2 + DNA<br />
**[[3s7r]] - h-hnRNP A/B<br />
**[[1x4b]] - h-hnRNP A2/B1 RRM – NMR<br />
**[[1txp]] - h-hnRNP C oligomerization domain – NMR<br />
**[[1wf2]] - h-hnRNP C1/C2 RRM – NMR<br />
**[[1hd0]], [[1hd1]], [[1iqt]] - h-hnRNP D0 RRM – NMR<br />
**[[2hgl]], [[2hgm]], [[2hgn]] - h-hnRNP F QRRM – NMR<br />
**[[1wg5]], [[1wez]], [[2lxu]] - h-hnRNP H RRM – NMR<br />
**[[2ad9]], [[2adb]], [[2adc]] - h-hnRNP I – NMR<br />
**[[1zzk]] - h-hnRNP K KH domain<br />
**[[3r27]], [[3t08]] - h-hnRNP L RRM<br />
**[[2do0]], [[2dh9]], [[2dgv]] - h-hnRNP M RRM – NMR<br />
**[[2dgu]] - h-hnRNP Q RRM – NMR<br />
**[[2dk2]] - h-hnRNP R RRM – NMR<br />
 
*Heterogenous nuclear ribonucleoprotein binary complex


**[[2kfy]], [[2kg0]], [[2kg1]] - h-hnRNP F QRRM + DNA – NMR<br />
**[[2z5n]], [[2z5o]], [[2ot8]] - h-hnRNP D0 CTD + transportin-1<br />
**[[1u1k]], [[1u1l]], [[1u1m]], [[1u1n]], [[1u1o]], [[1u1p]], [[1u1q]], [[1u1r]], [[1up1]] - h-hnRNP A1 RRM + DNA<br />
**[[1pgz]], [[1po6]] - h-hnRNP A1 + DNA + inhibitor<br />
**[[1wtb]], [[1x0f]] - h-hnRNP D0 RRM + DNA – NMR<br />
**[[1zzi]], [[1zzj]] - h-hnRNP K KH domain + DNA<br />
**[[1j5k]] - h-hnRNP K KH domain + DNA – NMR
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Alexander Berchansky, Michal Harel, Joel L. Sussman, Jaime Prilusky
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