Anthrax edema factor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 == Function ==
-'''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin.  The full anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF.   The EF is a calcium- and calmodulin-dependent adenylate cyclase.  The binding of calmodulin to EF changes it from its non-active form to the active one.<ref>PMID:15680766</ref>
+'''Anthrax edema factor''' (EF) or '''calmodulin-sensitive adenylate cyclase''' is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin.  The full anthrax toxin is composed of -<BR />
+*A cell-binding protein [[Anthrax protective antigen]]<BR />
+*[[Anthrax Lethal Factor]]<BR />
+*and anthrax edema factor.<br />
+The EF is a calcium- and calmodulin-dependent adenylate cyclase.  The binding of calmodulin to EF changes it from its non-active form to the active one.<ref>PMID:15680766</ref> See also [[Toxins]].
 == Disease ==
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 *<scene name='48/485623/Cv/2'>EF trimer with 3 calmodulin molecules</scene>.
-*<scene name='48/485623/Cv/3'>ADP derivative/Yt+3 binding site</scene> of EF.
+*<scene name='48/485623/Cv/5'>ADP derivative/Yt+3 binding site</scene> of EF. Water molecules are shown as red spheres.
-*<scene name='48/485623/Cv/4'>Ca+2 binding site</scene> of calmodulin (PDB code [[1pk0]]).<ref>PMID:14978283</ref>
+*<scene name='48/485623/Cv/6'>Ca+2 binding site</scene> of calmodulin (PDB code [[1pk0]]).<ref>PMID:14978283</ref>
-</StructureSection>
 ==3D structures of anthrax edema factor==
+[[Anthrax edema factor 3D structures]]
+</StructureSection>
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1lvc]] – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP<br />
-[[1pk0]] - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP<br />
-[[1s26]] - EF adenylate cyclase domain C terminal + calmodulin + methylene-ATP<br />
-[[1sk6]] - EF adenylate cyclase domain C terminal + calmodulin + pyrophosphate + cAMP<br />
-[[1xfu]] - EF (mutant) + calmodulin<br />
-[[1xfv]] - EF + calmodulin + deoxy-ATP<br />
-[[1xfw]] - EF + calmodulin + cAMP<br />
-[[1xfx]], [[1xfy]], [[1xfz]] - EF + calmodulin
 == References ==
 <references/>
 [[Category:Topic Page]]