Anthrax edema factor: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
-{{STRUCTURE_1pk0|  PDB=1pk0  | SIZE=400| SCENE= |right|CAPTION=EF trimer (grey, green, pink) complex with calmodulin (yellow, magenta, cyan) and adenine diphosphate derivative, Ca+2 (light green) and Yt+3 (green) ions [[1pk0]] }}
+<StructureSection load='1pk0' size='350' side='right' caption='EF trimer (magenta, cyan, salmon) complex with calmodulin (yellow) and adenine diphosphate derivative, Ca+2 (light green) and Yt+3 (green) ions (PDB code [[1pk0]]).' scene='48/485623/Cv/1'>
-<!--
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
-Or use the four-green-boxes-button to insert scrollable text adjacent
-to a Jmol applet. Check out the other buttons as well!
--->
 == Function ==
-'''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin.  The full anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF.   The EF is a calcium- and calmodulin-dependent adenylate cyclase.  The binding of calmodulin to EF changes it from its non-active form to the active one.
+'''Anthrax edema factor''' (EF) or '''calmodulin-sensitive adenylate cyclase''' is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin.  The full anthrax toxin is composed of -<BR />
+*A cell-binding protein [[Anthrax protective antigen]]<BR />
+*[[Anthrax Lethal Factor]]<BR />
+*and anthrax edema factor.<br />
+The EF is a calcium- and calmodulin-dependent adenylate cyclase.  The binding of calmodulin to EF changes it from its non-active form to the active one.<ref>PMID:15680766</ref> See also [[Toxins]].
 == Disease ==
 The anthrax disease is caused by the invasion of cells by the bacteria followed by increasing the cellular level of cAMP thus upsetting water homeostasis and causing disruption of signaling pathways.
+== Structural highlights ==
+*<scene name='48/485623/Cv/2'>EF trimer with 3 calmodulin molecules</scene>.
+*<scene name='48/485623/Cv/5'>ADP derivative/Yt+3 binding site</scene> of EF. Water molecules are shown as red spheres.
+*<scene name='48/485623/Cv/6'>Ca+2 binding site</scene> of calmodulin (PDB code [[1pk0]]).<ref>PMID:14978283</ref>
 ==3D structures of anthrax edema factor==
+[[Anthrax edema factor 3D structures]]
+</StructureSection>
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1lvc]] – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP<br />
-[[1pk0]] - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP<br />
-[[1s26]] - EF adenylate cyclase domain C terminal + calmodulin + methylene-ATP<br />
-[[1sk6]] - EF adenylate cyclase domain C terminal + calmodulin + pyrophosphate + cAMP<br />
-[[1xfu]] - EF (mutant) + calmodulin<br />
-[[1xfv]] - EF + calmodulin + deoxy-ATP<br />
-[[1xfw]] - EF + calmodulin + cAMP<br />
-[[1xfx]], [[1xfy]], [[1xfz]] - EF + calmodulin
+== References ==
+<references/>
 [[Category:Topic Page]]