Pseudoenzyme: Difference between revisions

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Wayne Decatur, Eric Martz, Alexander Berchansky

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-== Pseudoenzyme ==
+__NOTOC__
-[[Pseudoenzyme|pseudoenzymes]] are proteins that cannot catalyze chemical reactions despite being clearly related structurally to functioning enzymes.  Many enzyme families contain inactive members. For example, a number of human kinases lack at least one of the key amino acids necessary for catalysis of phosphate transfer. Often [[Pseudoenzyme|pseudoenzymes]] still have biological roles, albeit non-catalytic. Some assist true enzymes in obtaining functional folds, some server as platforms for other proteins to interact, and some are escorts for proteins <ref>PMID: 23559232</ref><ref>PMID: 23559233</ref>.
+[[Pseudoenzyme|Pseudoenzymes]] are proteins that cannot catalyze chemical reactions despite being clearly related structurally to functioning enzymes.  Many enzyme families contain inactive members. For example, a number of human kinases lack at least one of the key amino acids necessary for catalysis of phosphate transfer <ref>PMID: 12471243</ref>. Often [[Pseudoenzyme|pseudoenzymes]] still have biological roles, albeit non-catalytic. Some assist true enzymes in obtaining functional folds, some server as platforms for other proteins to interact, and some are escorts for proteins <ref>PMID: 23559232</ref><ref>PMID: 23559233</ref>.
 ==3D structures of Pseudoenzymes==
+* Toxoplasma virulence factor, ROP5 [[pseudokinase]] ([[3q5z]] and [[3q60]])
 * C-terminal domain of splicing factor Prp8p ([[2og4]]) resembles an isopeptidase converted to a platform
-* the structure of a fragment of integrin-like kinase ([[GET PDB ID]]) demonstrated it is not a kinase and instead serves a structural role linking the cell's cytoskeleton to surface receptors GET PDB ID BY LOOKING UP
+* the structure of a fragment of integrin-like kinase ([[3kmu]] and [[3kmw]]) demonstrated it is not a kinase and instead serves a structural role linking the cell's cytoskeleton to surface receptors
+*RLCK family member, the Brassinosteroid signaling kinase ([[4i92]], [[ 4i93]], [[ 4i94]])
+* the [[pseudokinase]] MLKL ([[4btf]]) involved in triggering cell death by necroptosis
+*[[Journal:Acta Cryst D:S2059798319002912|Crystal structure of the pseudoenzyme PDX1.2 in complex with its cognate enzyme PDX1.3]]
+==Related==
+* [[pseudokinase]]
+* CASK ([[3c0i]], [[3c0h]], and [[3c0g]]) was originally thought to be a [Pseudoenzyme|pseudoenzyme]], but after the structural was solved it was apparent it could use alternative amino acids in the kinase reaction, see Mukherjee et al., 2008 <ref>PMID: 18423203 </ref> and Kanaan and Taylor, 2008 <ref>PMID:18423189</ref>
+* [[Conservation, Evolutionary]]
+* [[Evolution]]
+* [[Introduction to Evolutionary Conservation]]
 ==References==
 <references/>
-==Related==
-* [[GET PDB ID by LOOKING UP CASK and Konark Mukherjee -- may be a 2008 Cell paper, hard to tell from citation if same]] - CASK was originally thought to be a [Pseudoenzyme|pseudoenzyme]], but after the structural was solved it was apparent it could use alternative amino acids in the kinase reaction
 [[Category:Pseudoenzyme]]