Molecular Playground/Taxol: Difference between revisions
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< | <StructureSection load='' size='350' side='right' caption='Paclitaxel (also known as Taxol)' scene='Rohan_Patil/Sandbox1/Taxol/6'> | ||
caption='Paclitaxel (also known as Taxol)' | |||
[[Image:Paclitaxel.png|frame|Paclitaxel (Taxol, Bristol-Myers Squibb)]] | [[Image:Paclitaxel.png|frame|Paclitaxel (Taxol, Bristol-Myers Squibb)]] | ||
[[Image:Docetaxel.png|frame|Docetaxel (Taxotere, Sanofi-aventis)]]Paclitaxel is one of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]. | [[Image:Docetaxel.png|frame|Docetaxel (Taxotere, Sanofi-aventis)]] | ||
Paclitaxel is one of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]. | |||
Paclitaxel, also called Taxol (Bristol-Myers Squibb), is a plant derived anti-cancer agent that was first isolated from the bark of Pacific yew tree, ''Taxus brevifolia'', in 1971. It is a complex diterpenoid with a bulky, fused ring system as well as a number of hydrophobic substituents. Approved by the FDA in 1992, it is currently being used in the treatment of ovarian, breast and lung cancers. In addition, therapies are being developed for treatment of Alzheimer's and post-heart surgery patients. | Paclitaxel, also called Taxol (Bristol-Myers Squibb), is a plant derived anti-cancer agent that was first isolated from the bark of Pacific yew tree, ''Taxus brevifolia'', in 1971. It is a complex diterpenoid with a bulky, fused ring system as well as a number of hydrophobic substituents. Approved by the FDA in 1992, it is currently being used in the treatment of ovarian, breast and lung cancers. In addition, therapies are being developed for treatment of Alzheimer's and post-heart surgery patients. | ||
Molecular Playground Banner: "Paclitaxel (Taxol),a plant-derived natural product to treat cancer" | Molecular Playground Banner: "Paclitaxel (Taxol),a plant-derived natural product to treat cancer" | ||
< | <scene name='60/609785/Tubulin/2'>Paclitaxel binding to alpha-beta tubulin</scene> (PDB code [[1jff]]). | ||
==Production== | ==Production== | ||
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==Docetaxel== | ==Docetaxel== | ||
*<scene name='Molecular_Playground/Taxol/Docetaxel/4'>Docetaxel (also known as Taxotere)</scene>. | |||
Docetaxel (Taxotere, sanofi-aventis) is a semi-synthetic analog of Taxol that was discovered during the search for a more easily produced taxane anti-cancer agent. The hydroxyl group modification on docetaxel leads to an increase in the lipid solubility of the drug. It was first approved by the FDA in 1996 and is currently used in the treatment of breast, stomach and prostate cancer. Currently, Taxotere is produced from paclitaxel precursors which are extracted from ''Taxus brevifolia'', the readily available Wester Yew. | Docetaxel (Taxotere, sanofi-aventis) is a semi-synthetic analog of Taxol that was discovered during the search for a more easily produced taxane anti-cancer agent. The hydroxyl group modification on docetaxel leads to an increase in the lipid solubility of the drug. It was first approved by the FDA in 1996 and is currently used in the treatment of breast, stomach and prostate cancer. Currently, Taxotere is produced from paclitaxel precursors which are extracted from ''Taxus brevifolia'', the readily available Wester Yew. | ||
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Molecular Playground Banner: "Docetaxel (Taxotere), an analaog of the plant derived anti-cancer agent paclitaxel" | Molecular Playground Banner: "Docetaxel (Taxotere), an analaog of the plant derived anti-cancer agent paclitaxel" | ||
</StructureSection> | |||
==References== | ==References== | ||
<references/> | <references/> | ||