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▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br />
▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br />
▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br />
▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br />
▪ '''AT-III''' inactivates thrombin in plasma.  For details see [[Student Projects for UMass Chemistry 423 Spring 2012-7]].<br />
▪ '''AT-III''' inactivates thrombin in plasma.  For details see [[Student Projects for UMass Chemistry 423 Spring 2012-7|Student Projects for UMass Chemistry 423 Spring 2012-7 - Antithrombin III: Devourer of Memories]].<br />
▪ '''AT-IV''' becomes activated during blood coagulation.<br />
▪ '''AT-IV''' becomes activated during blood coagulation.<br />
See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]].
See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]].
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== Relevance ==
== Relevance ==
AT activity is enhanced upon <scene name='46/466527/Cv/3'>binding to the anticoagulant drug heparin</scene>.
AT activity is enhanced upon <scene name='46/466527/Cv/4'>binding to the anticoagulant drug heparin</scene>.


==Structural highlights==
==Structural highlights==


The binding of AT to the heparans or the heparin drug is to a core pentasaccharide. The binding induces conformational change of AT.
The binding of AT to the heparans or the heparin drug is to a core pentasaccharide. The binding induces conformational change of AT.
</StructureSection>


==3D structures of antithrombin==
==3D structures of antithrombin==
[[Antithrombin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Antithrombin
 
**[[1att]] – AT-III – bovine
 
**[[1ant]], [[2ant]] – hAT – human
 
**[[1e05]] - hα-AT-III
 
**[[1e04]] – hβ-AT-III
 
**[[1ath]], [[2znh]], [[4eb1]] – hAT-III
 
**[[1dzg]], [[1oyh]], [[1t1f]], [[2beh]], [[2b4x]], [[2hij]] - hAT-III (mutant)
 
*Antithrombin binary complexes
 
**[[1azx]], [[1nq9]], [[3evj]], [[1e03]] – hAT III + heparin pentasaccharide
 
**[[1dzh]] - hAT-III (mutant) + fluorescein
 
**[[2gd4]] - hAT-III (mutant) + coagulation factor X
 
**[[1br8]], [[1jvq]], [[1lk6]], [[1r1l]] – hAT-III + peptide
 
*Antithrombin ternary complexes
 
**[[1sr5]] - hAT-III + prothrombin + heparin heptasaccharide
 
**[[1tb6]] - hAT-III (mutant) + thrombin + heparin polysaccharide
 
**[[2b5t]] - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide


**[[3kcg]] - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel, Alexander Berchansky
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