Antithrombin: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
No edit summary |
||
| (5 intermediate revisions by 2 users not shown) | |||
| Line 8: | Line 8: | ||
▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br /> | ▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br /> | ||
▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br /> | ▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br /> | ||
▪ '''AT-III''' inactivates thrombin in plasma.<br /> | ▪ '''AT-III''' inactivates thrombin in plasma. For details see [[Student Projects for UMass Chemistry 423 Spring 2012-7|Student Projects for UMass Chemistry 423 Spring 2012-7 - Antithrombin III: Devourer of Memories]].<br /> | ||
▪ '''AT-IV''' becomes activated during blood coagulation.<br /> | ▪ '''AT-IV''' becomes activated during blood coagulation.<br /> | ||
See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | ||
| Line 17: | Line 17: | ||
== Relevance == | == Relevance == | ||
AT activity is enhanced upon <scene name='46/466527/Cv/ | AT activity is enhanced upon <scene name='46/466527/Cv/4'>binding to the anticoagulant drug heparin</scene>. | ||
==Structural highlights== | ==Structural highlights== | ||
The binding of AT to the heparans or the heparin drug is to a core pentasaccharide. The binding induces conformational change of AT. | The binding of AT to the heparans or the heparin drug is to a core pentasaccharide. The binding induces conformational change of AT. | ||
==3D structures of antithrombin== | ==3D structures of antithrombin== | ||
[[Antithrombin 3D structures]] | |||
</StructureSection> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||