Antithrombin: Difference between revisions
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<StructureSection load='3evj' size='350' side='right' caption='Glycosylated human antithrombin III complex with heparin (in green) (PDB code [[3evj]])' scene='46/466527/Cv/1'> | |||
<StructureSection load='3evj' size=' | |||
== Function == | == Function == | ||
'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.<br /> | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.<ref>PMID:15311269</ref><br /> | ||
▪ '''α-AT''' contains 4 occupied glycosylation sites and is found in blood palsma.<br /> | ▪ '''α-AT''' contains 4 occupied glycosylation sites and is found in blood palsma.<br /> | ||
▪ '''β-AT''' contains only 3 occupied glycosylation sites.<br /> | ▪ '''β-AT''' contains only 3 occupied glycosylation sites.<br /> | ||
▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br /> | ▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br /> | ||
▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br /> | ▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br /> | ||
▪ '''AT-III''' inactivates thrombin in plasma.<br /> | ▪ '''AT-III''' inactivates thrombin in plasma. For details see [[Student Projects for UMass Chemistry 423 Spring 2012-7|Student Projects for UMass Chemistry 423 Spring 2012-7 - Antithrombin III: Devourer of Memories]].<br /> | ||
▪ '''AT-IV''' becomes activated during blood coagulation.<br /> | ▪ '''AT-IV''' becomes activated during blood coagulation.<br /> | ||
See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | ||
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== Relevance == | == Relevance == | ||
AT activity is enhanced upon binding to the anticoagulant drug heparin. | AT activity is enhanced upon <scene name='46/466527/Cv/4'>binding to the anticoagulant drug heparin</scene>. | ||
==Structural highlights== | ==Structural highlights== | ||
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==3D structures of antithrombin== | ==3D structures of antithrombin== | ||
[[Antithrombin 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||