Caspase-3 Regulatory Mechanisms: Difference between revisions
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<StructureSection load='2h5i_mm1-1.pdb' size=' | <StructureSection load='2h5i_mm1-1.pdb' size='450' side='right' caption='Caspase-3 (PDB entry [[2h5i]])' scene='Sandox_Bay_Serrano/Monomer/1'> | ||
== Introduction == | == Introduction == | ||
[[Image:Apop.png | thumb| Caspases in the apoptotic pathway]] | [[Image:Apop.png | thumb| Caspases in the apoptotic pathway]] | ||
{{Clear}} | |||
Caspases are '''''c'''''ysteine-'''''asp'''''artic acid prote'''''ases''''' and are key protein facilitators for the faithful execution of apoptosis or programmed cell death. Dysregulation in the apoptotic pathway has been implicated in a variety of diseases such as neurodegeneration, cancer, heart disease and some metabolic disorders. Because of the crucial role of caspases in the the apoptotic pathway, abnormalities in their functions would cause haywire in the apoptotic cascade and can be deleterious to the cell. Caspases are thus being considered as therapeutic targets in apoptosis-related diseases. | Caspases are '''''c'''''ysteine-'''''asp'''''artic acid prote'''''ases''''' and are key protein facilitators for the faithful execution of apoptosis or programmed cell death. Dysregulation in the apoptotic pathway has been implicated in a variety of diseases such as neurodegeneration, cancer, heart disease and some metabolic disorders. Because of the crucial role of caspases in the the apoptotic pathway, abnormalities in their functions would cause haywire in the apoptotic cascade and can be deleterious to the cell. Caspases are thus being considered as therapeutic targets in apoptosis-related diseases. | ||