Interleukin-10: Difference between revisions
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<StructureSection load='2h24' size='350' side='right' caption='' scene='Sandbox_165/Interleukin-10/1' pspeed='8'> | |||
[[Image:2h24.png|right|thumb| Figure 1. IL-10 N-Terminus of helix A ]] | [[Image:2h24.png|right|thumb| Figure 1. IL-10 N-Terminus of helix A ]] | ||
'''[[2h24|2H24]]''' is the PDB id assigned to Interleukin-10 (IL-10) after the determination of the crystal structure. IL-10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2 (R=receptor). The initial step is the formation of IL-10 and IL-10R1, a binary complex that generates a conformational change. This conformational change is required for IL-10R2 to be able to associate with the binary complex and form the ternary complex <ref name="ref1">PMID:16982608</ref>. | '''[[2h24|2H24]]''' is the PDB id assigned to Interleukin-10 (IL-10) after the determination of the crystal structure. IL-10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2 (R=receptor). The initial step is the formation of IL-10 and IL-10R1, a binary complex that generates a conformational change. This conformational change is required for IL-10R2 to be able to associate with the binary complex and form the ternary complex <ref name="ref1">PMID:16982608</ref>. | ||
The affinity of IL-10R1 and Il-10R2 are not considered to be dependent on the amino acid sequence but something more complex. There are several homolog IL-10s and mimic IL-10s that are able to bind and signal through the IL-10 receptor complex causing overlaying signals with cIL-10 <ref name="ref1"/>. The completed ternary complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK/STAT signaling pathway].[[Image:IL10.png|left|thumb|'''Figure 2. Sequential assembly of the ternary complex''' ]] The completion of the ternary complex is dependent on the conformational changes that occur in the N terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. There are structural features that allow for the large conformational changes, the structural features are a Cys-12 to Cys-108 disulfide bond at the N terminus and Leu-Leu-Leu motifat the C terminus of the AB loop<ref name="ref1"/>. | The affinity of IL-10R1 and Il-10R2 are not considered to be dependent on the amino acid sequence but something more complex. There are several homolog IL-10s and mimic IL-10s that are able to bind and signal through the IL-10 receptor complex causing overlaying signals with cIL-10 <ref name="ref1"/>. The completed ternary complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK/STAT signaling pathway].[[Image:IL10.png|left|thumb|'''Figure 2. Sequential assembly of the ternary complex''' ]] The completion of the ternary complex is dependent on the conformational changes that occur in the N terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. There are structural features that allow for the large conformational changes, the structural features are a Cys-12 to Cys-108 disulfide bond at the N terminus and Leu-Leu-Leu motifat the C terminus of the AB loop<ref name="ref1"/>. | ||
<scene name='Sandbox_165/2h24_backbone/1'>2h24 ball and stick</scene> | <scene name='Sandbox_165/2h24_backbone/1'>2h24 ball and stick</scene> | ||
=='''IL-10'''== | =='''IL-10'''== | ||
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There are many [http://en.wikipedia.org/wiki/interleukin interleukins] that fall within the cytokine class such as IL-1,IL-2,IL-3,IL-4...IL-31,IL-32,IL-33,IL-3 and IL-35. | There are many [http://en.wikipedia.org/wiki/interleukin interleukins] that fall within the cytokine class such as IL-1,IL-2,IL-3,IL-4...IL-31,IL-32,IL-33,IL-3 and IL-35. | ||
=Interleukin-10 and Rheumatoid Arthritis= | =Interleukin-10 and Rheumatoid Arthritis= | ||
[[Image:Illu_synovial_joint.jpg|left|thumb|'''Figure 3. Synovial Joint''' ]]<ref>http://en.wikipedia.org/wiki/Synovial_membrane</ref> | [[Image:Illu_synovial_joint.jpg|left|thumb|'''Figure 3. Synovial Joint''' ]]<ref>http://en.wikipedia.org/wiki/Synovial_membrane</ref> | ||
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</StructureSection> | |||
==3D structures of interleukin== | |||
[[Interleukin]] | |||
== '''References''' == | == '''References''' == | ||
<references/> | <references/> | ||