Recombination-activating gene: Difference between revisions
New page: ==Recombination Activating Gene Complex== <StructureSection load='3jbw' size='340' side='right' caption='Recombination Activating Gene Complex=''> The RAG complex protein is composed of tw... |
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==Recombination Activating Gene Complex== | ==Recombination-Activating Gene Complex== | ||
<StructureSection load='3jbw' size='340' side='right' caption=' | <StructureSection load='3jbw' size='340' side='right' caption='RAG1 (grey, pink) and RAG2 (green, yellow) complex with DNA and Zn+2 (grey) (PDB code [[3jbw]])'> | ||
The RAG complex protein is composed of two subunits, RAG-1 and RAG-2. RAG-1 and RAG-2 are critical in T and B cell maturation, promoting an adaptive immune response. | The '''RAG (Recombination Activating Gene) complex protein''' or '''V(D)J recombination-activating protein''' is composed of two subunits, RAG-1 and RAG-2. RAG-1 and RAG-2 are critical in T and B cell maturation, promoting an adaptive immune response. | ||
== Function == | == Function == | ||
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<scene name='77/778335/Rag2/1'> RAG2</scene> contains a plant homeodomain (PHD) near its C terminus (RAG2-PHD). This is unique because when a peptide is not being modified, a peptide N-terminal occupies the binding site, meaning that it is self-regulated. There is significantly less structural data on RAG2 due to a debate about the function of RAG2. Many challenge the belief that RAG2 cuts the RSS sequence, believing instead that RAG2 acts as a regulatory component to the complex. | <scene name='77/778335/Rag2/1'> RAG2</scene> contains a plant homeodomain (PHD) near its C terminus (RAG2-PHD). This is unique because when a peptide is not being modified, a peptide N-terminal occupies the binding site, meaning that it is self-regulated. There is significantly less structural data on RAG2 due to a debate about the function of RAG2. Many challenge the belief that RAG2 cuts the RSS sequence, believing instead that RAG2 acts as a regulatory component to the complex. | ||
== 3D Structures of recombination-activating gene == | |||
[[Recombination-activating gene 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||