Gp41: Difference between revisions

Latest revision as of 17:57, 17 November 2019

Function

Gp41 is a subunit of the envelope protein of retrovirus^[1]. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see HIV-1 viral envelope proteins.

Relevance

Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell^[2].

3D Structures of Gp41

Gp41 3D Structures

Core structure of acetylated gp41 from the HIV envelope glycoprotein, 1aik.

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Chan DC, Kim PS. HIV entry and its inhibition. Cell. 1998 May 29;93(5):681-4. PMID:9630213
↑ Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004;10(15):1805-25. PMID:15180542

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Chan DC, Kim PS. HIV entry and its inhibition. Cell. 1998 May 29;93(5):681-4. PMID:9630213

[2] Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004;10(15):1805-25. PMID:15180542

[1]

[2]

@@ Line 1: / Line 1: @@
 <StructureSection load='1aik' size='340' side='right' caption='Core structure of acetylated gp41 from the HIV envelope glycoprotein, [[1aik]].' scene=''>
 == Function ==
-'''Gp41''' is a subunit of the envelope protein of retrovirus<ref>PMID:9630213</ref>.  Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120.  For more details see [[Hiv env proteins]].
+'''Gp41''' is a subunit of the envelope protein of retrovirus<ref>PMID:9630213</ref>.  Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120.  For more details see [[Hiv env proteins|HIV-1 viral envelope proteins]].
 == Relevance ==
 Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell<ref>PMID:15180542</ref>.
-</StructureSection>
 == 3D Structures of Gp41 ==
+[[Gp41 3D Structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Gp41 from HIV-1; Domains – core 509-661; N-peptide 541-590; transmembrane 670-709; tail 750-854
-**[[2zfc]], [[3u91]] – Gp41 N-terminal residues 1-49 <br />
-**[[3k9a]] – Gp41 residues 1-108 (mutant)<br />
-**[[1aik]], [[1df4]], [[1df5]], [[1qr8]], [[1qr9]], [[1dlb]], [[1jpx]], [[1szt]], [[3vu5]], [[3vu6]] - Gp41 N-peptide domain <br />
-**[[1env]], [[3cp1]], [[3cyo]], [[1f23]], [[1k33]], [[1k34]], [[1i5x]], [[1i5y]], [[2ot5]], [[5ka6]], [[5ka5]], [[4i2l]] – Gp41 N-peptide domain (mutant)<br />
-**[[2z2t]], [[2zzo]], [[3aha]], [[3vie]], [[2r3c]], [[2r5b]], [[2r5d]], [[3l36]], [[3l37]], [[3vgy]], [[3vh7]], [[3vtp]], [[5h0n]]  – Gp41 N-peptide domain + fusion inhibitor peptide<br />
-**[[6b3u]] – Gp41 transmembrane domain - NMR<br />
-**[[5vwl]] – Gp41 tail domain - NMR<br />
-**[[5v8l]], [[5v8m]], [[5uty]], [[5utf]], [[5um8]], [[5jsa]], [[5js9]], [[5i8h]], [[5d9q]], [[5cjx]], [[5c7k]], [[6ck9]], [[6chb]], [[6ch9]], [[6ch8]], [[6ch7]], [[5w6d]], [[4nrx]], [[5fyk]], [[5fyj]], [[4nco]] – Gp41 core + Gp120 + antibody<br />
-**[[6cdi]] – Gp41 core + Gp120 + antibody – Cryo EM<br />
-**[[5u1f]], [[5thr]] – Gp41 core + Gp120 + antibody + CD4<br />
-**[[5hm1]] – Gp41 core + llama  antibody <br />
-**[[3o3x]] – arGp41 - artificial<br />
-**[[4dzu]] – arGp41 + 3-α<br />
-**[[4dzv]] – arGp41 + 4-α/β<br />
-*Gp41 from Simian Immunodeficiency Virus
-**[[2siv]] – Gp41 core<br />
-**[[2ezo]], [[2ezp]], [[2ezq]], [[2ezr]], [[2ezs]], [[1qce]] – Gp41 core - NMR<br />
-**[[1qbz]], [[1jq0]] – Gp41 core (mutant)<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]