Gp41: Difference between revisions

Latest revision as of 17:57, 17 November 2019

Function

Gp41 is a subunit of the envelope protein of retrovirus^[1]. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see HIV-1 viral envelope proteins.

Relevance

Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell^[2].

3D Structures of Gp41

Gp41 3D Structures

Core structure of acetylated gp41 from the HIV envelope glycoprotein, 1aik.

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Chan DC, Kim PS. HIV entry and its inhibition. Cell. 1998 May 29;93(5):681-4. PMID:9630213
↑ Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004;10(15):1805-25. PMID:15180542

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Chan DC, Kim PS. HIV entry and its inhibition. Cell. 1998 May 29;93(5):681-4. PMID:9630213

[2] Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004;10(15):1805-25. PMID:15180542

[1]

[2]

@@ Line 1: / Line 1: @@
-[[Image:1aik.png|left|200px|thumb|Crystal Structure of Gp41 [[1aik]]]]
+<StructureSection load='1aik' size='340' side='right' caption='Core structure of acetylated gp41 from the HIV envelope glycoprotein, [[1aik]].' scene=''>
-{{STRUCTURE_1aik|  PDB=1aik  | SIZE=400| SCENE= |right|CAPTION=Gp41, [[1aik]].  }}
+== Function ==
+'''Gp41''' is a subunit of the envelope protein of retrovirus<ref>PMID:9630213</ref>.  Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120.  For more details see [[Hiv env proteins|HIV-1 viral envelope proteins]].
+== Relevance ==
+Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell<ref>PMID:15180542</ref>.
+== 3D Structures of Gp41 ==
+[[Gp41 3D Structures]]
+</StructureSection>
+== References ==
+<references/>
+[[Category:Topic Page]]
-'''Gp41''' is a subunit of the envelope protein of retrovirus.  Gp41 is a transmembrane protein and contains several siteswhich are involved in the infection of the host cells. For more details see [[Hiv env proteins]].
-== 3D Structures of Actinin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-===Gp41 from HIV-1===
-[[1aik]] – Gp41 <br />
-[[1env]], [[3k9a]] – Gp41 (mutant)<br />
-[[1szt]] – Gp41 thermostable domain<br />
-[[3cp1]], [[3cyo]] – Gp41 thermostable domain (mutant)<br />
-[[1df4]], [[1df5]], [[1qr8]], [[1qr9]], [[1dlb]], [[1jpx]] – Gp41 core<br />
-[[1f23]], [[1k33]], [[1k34]], [[1i5x]], [[1i5y]], [[2ot5]] – Gp41 core (mutant)<br />
-[[2z2t]], [[2zzo]], [[3aha]], [[3vie]], [[2r3c]], [[2r5b]], [[2r5d]], [[3l36]], [[3l37]], [[3vgy]], [[3vh7]], [[3vtp]], [[3vu5]], [[3vu6]]  – Gp41 N-heptad repeat + Gp41 fusion inhibitor peptide<br />
-[[2zfc]] – Gp41 N-peptide <br />
-===Gp41 from Simian Immunodeficiency Virus===
-[[2siv]] – Gp41 core<br />
-[[2ezo]], [[2ezp]], [[2ezq]], [[2ezr]], [[2ezs]], [[1qce]] – Gp41 core - NMR<br />
-[[1qbz]], [[1jq0]] – Gp41 core (mutant)<br />