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| == Function == | | == Function == |
| '''Glycoprotein Gp120''', named for its molecular weight, is found on the surface of HIV envelope. Gp120 is associated with Gp41. It is involved in the binding of HIV to CD4 receptors thus attaching the virus to the host cell<ref>PMID:11244037</ref>. For more details see<br /> | | '''Glycoprotein Gp120''', named for its molecular weight, is found on the surface of HIV envelope. Gp120 is associated with Gp41. It is involved in the binding of HIV to CD4 receptors thus attaching the virus to the host cell<ref>PMID:11244037</ref>. For more details see<br /> |
| *[[Hiv env proteins]]<br /> | | *[[Hiv env proteins|HIV-1 viral envelope proteins]]<br /> |
| *[[VRC01 gp120 complex]]. | | *[[VRC01 gp120 complex]]. |
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| </StructureSection> | | </StructureSection> |
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| ==3D structures of Gp120==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Gp120 from HIV-1; Domains – Clade A/E 1-140; outer – 1-181; RHPA 1-216; V1-V2 118-246; V3 296-331; core 44-492; C5 484-506
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| **[[3dnl]], [[3dnn]], [[3dno]], [[3tgq]], [[3tgr]], [[3tgt]], [[3tih]], [[5f4u]] - Gp120 core<br />
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| **[[5fa2]] - Gp120 core (mutant)<br />
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| **[[1meq]] – GP120 C5 domain – NMR<br />
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| **[[1niz]], [[1nj0]], [[2esx]], [[2esz]], [[1u6u]], [[1u6v]] - GP120 V3 loop – NMR<br />
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| **[[4jpj]], [[5idl]] - Gp120 outer domain<br />
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| *Gp120 binary complex
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| **[[4jb9]], [[4lsp]], [[4lsq]], [[4lsr]], [[4lsu]], [[5te6]], [[5fcu]], [[5f9w]], [[5f9o]], [[5f96]], [[5cd5]], [[4xvt]] - Gp120 Clade A/E + antibody <br />
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| **[[4yc2]], [[4ybl]], [[4s1s]], [[4s1r]], [[4s1q]] - Gp120 Clade A/E (mutant) + antibody <br />
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| **[[4i3r]], [[4i3s]], [[5kzc]], [[5if0]], [[5ies]], [[4jpv]] - Gp120 outer domain + antibody<br />
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| **[[5t33]] - Gp120 RHPA + antibody <br />
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| **[[3u2s]] - Gp120 V1V2 region + antibody PG9<br />
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| **[[3se8]], [[3se9]], [[3hi1]], [[3rjq]], [[4jkp]], [[4jm2]], [[4lss]], [[4lsv]], [[4ywg]], [[4xvs]], [[3ngb]], [[4ye4]], [[4rwy]], [[4jan]], [[4lst]], [[5te7]], [[5f6j]], [[5te4]], [[6bf4]], [[5wb9]], [[5w6d]], [[5ukr]], [[5uem]], [[5igx]], [[4dvr]] - Gp120 + antibody<br />
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| **[[3idx]], [[3idy]], [[2ny7]]. [[4jdt]], [[5fyl]], [[5fec]], [[6bck]] - Gp120 core (mutant) + antibody <br />
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| **[[4rz8]], [[5f4l]], [[5f4p]], [[5f4r]] - Gp120 core + CD4 mimic <br />
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| **[[4dku]], [[4dkv]] - Gp120 core (mutant) + CD4 mimetic<br />
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| **[[4jzw]], [[4jzz]], [[4k0a]], [[4ka2]] - Gp120 core + CD4 mimetic miniprotein<br />
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| **[[4jpj]], [[4rx4]] - Gp120 Clade A + antibody <br />
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| **[[3tgs]], [[4dko]], [[4dkp]], [[4dkq]], [[4dkr]] - Gp120 core + piperidine derivative<br />
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| **[[5u6e]] - Gp120 core + pyrrole derivative<br />
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| **[[4dvx]], [[4dvw]], [[4dvv]], [[4dvt]], [[4dvs]] - Gp120 core (mutant) + piperazine derivative<br />
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| *Gp120 ternary complex
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| **[[5kjr]] - Gp120 Clade A/E + M48U1 peptide + antibody<br />
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| **[[4rfo]], [[4rfn]] - Gp120 Clade A/E (mutant) + M48U1 peptide + antibody<br />
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| **[[4h8w]] - Gp120 Clade A/E + CD4 + antibody<br />
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| **[[3jwd]], [[3jwo]], [[2i5y]], [[2i60]] - Gp120 core + hCD4 N terminal + antibody <br />
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| **[[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[1yyl]], [[1yym]], [[2b4c]] - Gp120 core (mutant) + hCD4 N terminal + antibody <br />
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| **[[5a8h]], [[5a7x]], [[4rqs]], [[4r4h]], [[4r2g]], [[4p9h]] - Gp120 core + hCD4 D1-D2 domain + antibody<br />
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| **[[4laj]] - Gp120 core + CD4 mimetic miniprotein + antibody<br />
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| **[[5w4l]], [[5uwe]] - Gp120 core (mutant) + CD4 mimetic peptide + antibody<br />
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| **[[4r4f]], [[4r4n]] - Gp120 core + M48U1 peptide + antibody<br />
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| **[[5v8l]], [[5v8m]], [[5uty]], [[5utf]], [[5um8]], [[5jsa]], [[5js9]], [[5i8h]], [[5d9q]], [[5cjx]], [[5c7k]], [[6ccb]], [[6mft]], [[6mdt]], [[6mco]], [[6d2p]], [[6ck9]], [[6ch9]], [[6ch8]], [[6ch7]] - Gp120 core + Gp41 + antibody<br />
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| **[[5fyk]], [[5fyj]], [[4nco]], [[6nnj]], [[6nnf]], [[6nm6]] - Gp120 core (mutant) + Gp41 + antibody<br />
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| **[[6cde]], [[6cdi]], [[6orn]], [[6oro]], [[6orp]], [[6orq]], [[6okp]], [[6nqd]], [[6nc3]], [[6nc2]], [[6mn7]], [[6e5p]], [[6cuf]], [[6cue]], [[6chb]], [[5u1f]], [[5thr]], [[4cc8]], [[3j70]] - Gp120 core + Gp41 + antibody – Cryo EM<br />
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| **[[3j5m]] - Gp120 core (mutant) + Gp41 + antibody – Cryo EM<br />
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| *Gp120 from HIV-2 binary complex
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| **[[5fec]], [[5cay]] - Gp120 core (mutant) + CD4<br />
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| *Gp120 from SIV
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| **[[2bf1]], [[3fus]] - Gp120 core<br />
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| **[[3jcc]], [[3jcb]] - Gp120 core + CD4 + antibody – Cryo EM<br />
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| }}
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| == References == | | == References == |