Phosphocarrier protein: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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+<StructureSection load='' size='350' side='right' caption='Structure of phosphocarrier protein HPr (PDB entry [[1fu0]])' scene='57/570591/Cv/1'>
+__TOC__
+== Function ==
+'''Phosphocarrier protein HPr''' (HPr) is a component of the sugar phosphotransferase system.  The system catalyses the phosphorylation of sugars during their translocation across cell membrane.  A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr<ref>PMID:8246840</ref>.  A conserved histidine in the N terminal of HPr is the acceptor of the phosphate.  In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated.
-<StructureSection load='1fu0' size='350' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1fu0]])' scene=''>
+'''Phosphocarrier protein NPr''' (NPr) is a component of the sugar phosphotransferase system.  NPr is a phosphoryl transfer protein, homologous to HPr which functions to regulate nitrogen metabolism<ref>PMID:18421563</ref>.
-'''Phosphocarrier protein HPr''' (HPr) is a component of the sugar phosphotransferase system.  The system catalyses the phosphorylation of sugars during their translocation across cell membrane.  A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr.  A conserved histidine in the N terminal of HPr is the acceptor of the phosphate.  In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated.
+'''Phosphocarrier protein III Glc''' (PcpIII) is a signal-transducing component of the phosphoenolpyruvate:glycose  phosphotransferase system of ''E. coli''<ref>PMID:11168402</ref>.
-[[2hpr]] - BsHPr (mutant) – ''Bacillus subtilis'' <br />
+== Structural highlights ==
-[[2hid]] - BsHPr (mutant) – NMR <br />
+The <scene name='57/570591/Cv/3'>phosphorylation of Ser46</scene> prohibits the HPr to act as a phosphocarrier in the EI reaction<ref>PMID:11054290</ref>.
-[[1jem]] - BsHPr (mutant) with phosphohistidine – NMR <br />
-[[1sph]] – BsHPr <br />
-[[1poh]] – EcHPr – ''Escherichia coli''  <br />
-[[1opd]], [[1cm2]], [[1cm3]], [[3ccd]] - EcHPr (mutant)  <br />
-[[1hdn]] - EcHPr – NMR  <br />
-[[1pfh]] - EcHPr with phosphohistidine – NMR  <br />
-[[1ptf]] - EfHPr – ''Enterococcus faecalis'' <br />
-[[1qfr]] - EfHPr – NMR <br />
-[[1fu0]] - EfHPr with phosphoserine  <br />
-[[1pch]] – HPr – ''Mycoplasma capricolum''<br />
-[[1qr5]] - ScHPr – ''Staphylococcus carnosus'' - NMR <br />
-[[1txe]] - ScHPr (mutant) – NMR <br />
-[[1ka5]] - HPr – ''Staphylococcus aureus'' - NMR <br />
-[[1y4y]] – GsHPr – ''Geobacillus stearothermophilus''<br />
-[[1y50]], [[1y51]] - GsHPr (mutant)  <br />
-[[3ihs]] – HPr – ''Bacillus anthracis'' <br />
-===HPr complex===
+==3D structures of phosphocarrier protein HPr==
+[[Phosphocarrier protein HPr 3D structures]]
-[[2jel]] - EcHPr + antibody <br />
+</StructureSection>
-[[3eze]], [[3ezb]] - EcHPr + EI N terminal + PO3 – NMR  <br />
-[[2xdf]] - EcHPr + EI N terminal – NMR  <br />
+== References ==
-[[1ggr]], [[1j6t]], [[1vrc]] - EcHPr + EII N terminal + PO3 – NMR  <br />
+<references/>
-[[2lrk]], [[2lrl]] - EcHPr + EII N terminal – NMR  <br />
+[[Category:Topic Page]]
-[[1kkl]] - BsHPr (mutant) + HPrK <br />
-[[1kkm]] - BsHPr (mutant) with phosphoserine + HPrK/P <br />
-[[2fep]] - BsHPr with phosphoserine + BsCcpA <br />
-[[1rzr]] – BmHPr with phosphoserine + BmCcpA + DNA  - ''Bacillus megaterium''<br />
-[[2oen]] - BmHPr with phosphoserine + BmCcpA<br />
-[[2nzu]] - BmHPr with phosphoserine + BmCcpA + glucose-6-phosphate  <br />
-[[2nzv]] - BmHPr with phosphoserine + BmCcpA + fructose-1,6-diphosphate  <br />
-[[3oqm]], [[3oqn]], [[3oqo]] - BsHPr with phosphoserine + BsCcpA + DNA<br />