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| {{STRUCTURE_2f9w| PDB=2f9w | SIZE=400| SCENE= |right|CAPTION=Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]] }}
| | <StructureSection load='' size='350' side='right' caption='Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]]' scene='52/525168/Cv/1' pspeed='8'> |
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| '''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX. | | == Function == |
| | '''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis<ref>. PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959</ref>.<br /> |
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| ==3D structures of pantothenate kinase==
| | Three types of PanK are known.<br > |
| | * '''PanK I''' found in bacteria<br /> |
| | * '''PanK II''' found mostly in eukaryotes<br /> |
| | * '''PanK III''' found in bacteria and known as CoaX. |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | == Disease == |
| | Mutations in PanK II cause the autosomal-recessive disorder Pantothenate kinase-associated neurodegeneration<ref>PMID:15911822</ref>. |
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| [[1esm]] – EcPanK + CoA – ''Escherichia coli''<br />
| | == Structural highlights == |
| [[1esn]] - EcPanK + ANP<br />
| | <scene name='52/525168/Cv/5'>Pantothenate binds in a buried pocket at the PanK dimer interface</scene><ref>PMID:16905099</ref>. |
| [[1sq5]] - EcPanK + ADP + PAU<br />
| | *<scene name='52/525168/Cv/6'>Buried pocket at the PanK dimer interface</scene>. |
| [[3tqc]] - PanK – ''Coxiella burnetii''
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| ==PanK I binary complex== | | ==3D structures of pantothenate kinase== |
| | | [[Pantothenate kinase 3D structures]] |
| [[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br />
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| [[2zs8]], [[2zsb]] - MtPanK + ADP<br />
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| [[3af1]] - MtPanK + GDP <br />
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| [[3af2]] - MtPanK + AMPPCP<br />
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| [[3af4]] - MtPanK + GMPPCP<br />
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| [[2zsd]] - MtPanK + CoA<br />
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| [[3avo]] - MtPanK + PAU<br />
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| [[3avp]], [[3avq]] - MtPanK + PAU derivative<br />
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| [[4bfs]], [[4bft]], [[4bfu]], [[4bfv]], [[4bfw]], [[4bfx]] - MtPanK + triazole inhibitor<br />
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| [[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br />
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| ==PanK I ternary complex==
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| [[2zs9]] - MtPanK + ADP + PAU<br />
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| [[2zse]] - MtPanK + AMPPCP + PAU<br />
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| [[3af3]] - MtPanK + GMPPCP + PAU<br />
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| [[2zsf]] - MtPanK + ADP + ATP<br />
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| [[2zsa]] - MtPanK + ADP + PPT<BR />
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| [[3aez]] - MtPanK + GDP + PPT<BR />
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| [[3af0]] - MtPanK + GDP + PAU<br />
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| [[4f7w]], [[4ne2]] – KpPanK + ADP + pantothenamide derivative – ''Klebsiella pneumonia''<br />
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| [[4gi7]] – KpPanK + ADP + pantothenate analog<br />
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| ===PanK II===
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| [[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br />
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| [[4nb4]] - SaPanK + ADP + pantothenamide<br /> | |
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| ===PanK III===
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| [[2gtd]] - TmPanK – ''Thermotoga maritima''<br />
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| [[2f9t]] – PaPanK – ''Pseudomonas aeruginosa''<br />
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| [[2h3g]] - PanK – ''Bacillus anthracis''<br />
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| [[3djc]] - PanK – ''Legionella pneumophila''<br />
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| [[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br />
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| ==PanK III binary complex==
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| [[2f9w]] - PaPanK + PAU<br />
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| [[3bex]] - TmPanK + PAU<br />
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| [[3bf3]] - TmPanK + PPT<BR />
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| ==PanK III ternary complex==
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| [[3bf1]] - TmPanK + ADP + PAU<br />
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| [[4o5f]] - BtPanK + ADP + PAU <br />
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| ===Human PanK===
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| [[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br />
| | </StructureSection> |
| [[2i7p]], [[3mk6]] - hPanK 3 + CoA<br />
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| [[3sms]] – hPanK 3 + PAU analog
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| | == References == |
| | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |