Pantothenate kinase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='' size='350' side='right' caption='Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]]' scene='52/525168/Cv/1' pspeed='8'>
-'''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source.  This is the first step in coenzyme A biosynthesis.  PanK is regulated by feedback inhibition by CoA and its thioesters.  Three types of PanK are known.  PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX.
+== Function ==
+'''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source.  This is the first step in coenzyme A biosynthesis<ref>.  PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959</ref>.<br />
-==3D structures of pantothenate kinase==
+Three types of PanK are known.<br >
+* '''PanK I''' found in bacteria<br />
+* '''PanK II''' found mostly in eukaryotes<br />
+* '''PanK III''' found in bacteria and known as CoaX.
-[[1esm]] – EcPanK + CoA – ''Escherichia coli''<br />
+== Disease ==
-[[1esn]] - EcPanK + ANP<br />
+Mutations in PanK II cause the autosomal-recessive disorder Pantothenate kinase-associated neurodegeneration<ref>PMID:15911822</ref>.
-[[1sq5]] - EcPanK + ADP + PAU<br />
-[[3tqc]] - PanK – ''Coxiella burnetii''
-==PanK I binary complex==
+== Structural highlights ==
+<scene name='52/525168/Cv/5'>Pantothenate binds in a buried pocket at the PanK dimer interface</scene><ref>PMID:16905099</ref>.
+*<scene name='52/525168/Cv/6'>Buried pocket at the PanK dimer interface</scene>.
-[[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br />
+==3D structures of pantothenate kinase==
-[[2zs8]], [[2zsb]] - MtPanK + ADP<br />
+[[Pantothenate kinase 3D structures]]
-[[3af1]] - MtPanK + GDP <br />
-[[3af2]] - MtPanK + AMPPCP<br />
-[[3af4]] - MtPanK + GMPPCP<br />
-[[2zsd]] - MtPanK + CoA<br />
-[[3avo]] - MtPanK + PAU<br />
-[[3avp]], [[3avq]] - MtPanK + PAU derivative
-==PanK I ternary complex==
-[[2zs9]] - MtPanK + ADP + PAU<br />
-[[2zse]] - MtPanK + AMPPCP + PAU<br />
-[[3af3]] - MtPanK + GMPPCP + PAU<br />
-[[2zsf]] - MtPanK + ADP + ATP<br />
-[[2zsa]] - MtPanK + ADP + PPT<BR />
-[[3aez]] - MtPanK + GDP + PPT<BR />
-[[3af0]] - MtPanK + GDP + PAU<br />
-===PanK II===
-[[2ews]] - PanK + ANP – ''Staphylococcus aureus''
-===PanK III===
-[[2gtd]] - TmPanK – ''Thermotoga maritima''<br />
-[[2f9t]] – PaPanK – ''Pseudomonas aeruginosa''<br />
-[[2h3g]] - PanK – ''Bacillus anthracis''<br />
-[[3djc]] - PanK – ''Legionella pneumophila''<br />
-==PanK III binary complex==
-[[2f9w]] - PaPanK + PAU<br />
-[[3bex]] - TmPanK + PAU<br />
-[[3bf3]] - TmPanK + PPT<BR />
-==PanK III ternary complex==
-[[3bf1]] - TmPanK + ADP + PAU<br />
-===Human PanK===
+</StructureSection>
-[[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br />
+== References ==
-[[2i7p]], [[3mk6]] - hPanK 3 + CoA<br />
+<references/>
-[[3sms]] – hPanK 3 + PAU analog
+[[Category:Topic Page]]