|
|
| (13 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
| {{STRUCTURE_1xip| PDB=1xip | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }}
| | <StructureSection load='' size='350' side='right' caption='Yeast nucleoporin NUP159 N-terminal domain (PDB entry [[1xip]])' scene='Nucleoporin/Cv/1'> |
| [[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD). | | == Function == |
| | [[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)<ref>PMID:9159086</ref>. <br /> |
| | *'''NUP1P''' is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture<ref>PMID:8045927</ref>. <br /> |
| | *'''NUP2P''' is a yeast nucleoprotein required for bidirectional transport of importin α<ref>PMID:11046143</ref>. <br /> |
| | *'''NUP Gle1''' is a yeast and human nucleoprotein required mRNA export. <br /> |
| | |
| | == Disease == |
| | NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids<ref>PMID:14693424</ref>. |
|
| |
|
| == 3D Structures of Nucleoporin == | | == 3D Structures of Nucleoporin == |
| | [[Nucleoporin 3D structures]] |
|
| |
|
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| |
| | |
| *NUP2
| |
| **[[3n7c]] – NUP2 RANBD – ''Ashbya gossypii''<br />
| |
| **[[2c1t]] – yNUP2 NTD +importrin alpha subunit - yeast<br />
| |
| *NUP35
| |
| **[[1wwh]] – mNUP35 MPPN domain - mouse<br />
| |
| *NUP37
| |
| **[[4fhl]] – fyNUP37 – fission yeast<br />
| |
| **[[4fhm]], [[4fhn]], [[4gq2]] - fyNUP37 + NUP120<br />
| |
| *NUP43
| |
| **[[4i79]] – hNUP43 + polypeptide<br />
| |
| *NUP50
| |
| **[[2ec1]] – hNUP50 RANBD - human<br />
| |
| **[[2c1m]] – mNUP50 NTD +importin <br />
| |
| **[[3tj3]] - hNUP50 NTD+importin<br />
| |
| *NUP53
| |
| **[[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii''<br />
| |
| **[[4lir]] – hNUP53 residues 151-266<br />
| |
| *NUP54
| |
| **[[3t97]] – rNUP54 + NUP62 - rat<br />
| |
| **[[4j3h]] – rNUP54 (mutant)<br />
| |
| **[[3t98]] – rNUP54 + rNUP58/45 <br />
| |
| *NUP58
| |
| **[[2osz]] – rNUP58/45 <br />
| |
| *NUP82
| |
| **[[3pbp]] – yNUP82 NTD + NUP116 CTD + NUP159 tail<br />
| |
| **[[3tkn]] - yNUP82 NTD + NUP98 + NUP159 tail<br />
| |
| *NUP84
| |
| **[[3jro]], [[3iko]] – yNUP84+NUP145+protein Sec13<br />
| |
| *NUP85
| |
| **[[3f3f]], [[3f3g]], [[3f3p]], [[3ewe]] – yNUP85+Seh1<br />
| |
| *NUP98
| |
| **[[3mmy]] – hNUP98 fragment+mRNA export factor <br />
| |
| **[[2q5x]], [[2q5y]] – hNUP98 CTD<br />
| |
| **[[1ko6]] – hNUP98 CTD<br />
| |
| *NUP100
| |
| **[[3nf5]] – NUP100 CTD – ''Candida glabrata''<br />
| |
| *NUP107
| |
| **[[3i4r]], [[3cqc]], [[3cqg]] – hNUP107+NUP133<br />
| |
| *NUP116
| |
| **[[2aiv]] – yNUP116 CTD - NMR<br />
| |
| *NUP120
| |
| **[[3f7f]], [[3h7n]], [[3hxr]] – yNUP120<br />
| |
| *NUP133
| |
| **[[1xks]] – hNUP133 NTD<br />
| |
| **[[3kfo]] – yNUP133 CTD <br />
| |
| *NUP145
| |
| **[[3bg0]], [[3bg1]] – hNUP145+Sec13-related protein<br />
| |
| **[[3kep]], [[3kes]] – yNUP145 autoproteolytic domain<br />
| |
| **[[3jrp]] - yNUP145+protein Sec13<br />
| |
| *NUP153
| |
| **[[3gj3]], [[3gj4]], [[3gj5]], [[3gj6]], [[3gj7]], [[3gj8]], [[3ch5]] – hNUP153+RAN<br />
| |
| **[[2ebq]], [[2ebr]], [[2ebv]], [[2gqe]] - hNUP153 RANBD – NMR<br />
| |
| **[[2k0c]] – rNUP153 RANBD – NMR<br />
| |
| *NUP157
| |
| **[[4mhc]] – hNUP157 NTD<br />
| |
| *NUP159
| |
| **[[1xip]] – yNUP159 NTD<br />
| |
| **[[3rrm]] – yNUP159 residues 2-387 + NUP Gle1 + IP6 + ADP<br />
| |
| *NUP170
| |
| **[[3i5p]], [[3i5q]] – yNUP170<br />
| |
| *NUP192
| |
| **[[4ifq]] – yNUP192<br />
| |
| *NUP214
| |
| **[[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br />
| |
| **[[2oit]] – hNUP214 NTD<br />
| |
| *NUP358
| |
| **[[1z5s]] – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN CTD<br />
| |
| **[[1xke]] - hNUP358 RANBD - NMR<br />
| |
| *NUP1P
| |
| **[[2bpt]] – yNUP1P+importin β subunit<br />
| |
| *NUP2P
| |
| **[[1un0]] – yNUP2P NTD+importrin α subunit<br />
| |
| *NUP-NSP1
| |
| **[[1o6o]] – yNUP-NSP1 residues 497-608+importrin β subunit<br />
| |
| *NUP-CDC31
| |
| **[[2doq]], [[2gv5]] – yNUP-CDC31+SFI1P<br />
| |
| **[[3fwb]], [[3fwc]] - yNUP-CDC31+SAC3<br />
| |
| | |
| *NUP Gle1
| |
| **[[3peu]], [[3pev]], [[3rrn]]– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6
| |
| | |
| **[[2rfo]], [[2qx5]] – yNic96<br />
| |
| **[[1gyb]] – NUP+yNTF2<br />
| |
| }}
| |
| | |
|
| |
|
| | == References == |
| | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |