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| [[Image:1xip.png|left|200px|thumb|Crystal structure of the N-terminal domain of yeast Nucleoporin NUP159, [[1xip]]]]
| | <StructureSection load='' size='350' side='right' caption='Yeast nucleoporin NUP159 N-terminal domain (PDB entry [[1xip]])' scene='Nucleoporin/Cv/1'> |
| {{STRUCTURE_1xip| PDB=1xip | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }}
| | == Function == |
| [[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD). The images at the left and at the right correspond to one representative Nucleoporin structure, ''i.e.'' crystal structure of yeast Nucleoporin NUP159 from ''Saccharomyces cerevisiae'' ([[1xip]]), | | [[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)<ref>PMID:9159086</ref>. <br /> |
| | *'''NUP1P''' is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture<ref>PMID:8045927</ref>. <br /> |
| | *'''NUP2P''' is a yeast nucleoprotein required for bidirectional transport of importin α<ref>PMID:11046143</ref>. <br /> |
| | *'''NUP Gle1''' is a yeast and human nucleoprotein required mRNA export. <br /> |
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| | == Disease == |
| | NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids<ref>PMID:14693424</ref>. |
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| {{TOC limit|limit=2}}
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| == 3D Structures of Nucleoporin == | | == 3D Structures of Nucleoporin == |
| | [[Nucleoporin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
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| ==NUP2==
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| [[3n7c]] – NUP2 RANBD – ''Ashbya gossypii''<br />
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| [[2c1t]] – yNUP2 NTD +importrin alpha subunit - yeast<br />
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| ==NUP35==
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| [[1wwh]] – mNUP35 MPPN domain - mouse<br />
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| ==NUP37==
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| [[4fhl]] – fyNUP37 – fission yeast<br />
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| [[4fhm]], [[4fhn]], [[4gq2]] - fyNUP37 + NUP120<br />
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| ==NUP43==
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| [[4i79]] – hNUP43 + polypeptide<br />
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| ==NUP50==
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| [[2ec1]] – hNUP50 RANBD - human<br />
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| [[2c1m]] – mNUP50 NTD +importin <br />
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| ==NUP53==
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| [[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii''
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| ==NUP54==
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| [[3t97]] – rNUP54 + NUP62 - rat<br />
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| [[4j3h]] – rNUP54 (mutant)<br />
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| ==NUP58==
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| [[2osz]] – rNUP58/45 <br />
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| ==NUP82==
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| [[3pbp]] – yNUP82 NTD + NUP116 CTD + NUP159 tail<br />
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| [[3tkn]] - yNUP82 NTD + NUP98 + NUP159 tail<br />
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| ==NUP84==
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| [[3jro]], [[3iko]] – yNUP84+NUP145+protein Sec13<br />
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| ==NUP85==
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| [[3f3f]], [[3f3g]], [[3f3p]], [[3ewe]] – yNUP85+Seh1<br />
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| ==NUP98==
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| [[3mmy]] – hNUP98 fragment+mRNA export factor <br />
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| [[2q5x]], [[2q5y]] – hNUP98 CTD<br />
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| [[1ko6]] – hNUP98 CTD<br />
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| ==NUP100==
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| [[3nf5]] – NUP100 CTD – ''Candida glabrata''<br />
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| ==NUP107==
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| [[3i4r]], [[3cqc]], [[3cqg]] – hNUP107+NUP133<br />
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| ==NUP116==
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| [[2aiv]] – yNUP116 CTD - NMR<br />
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| ==NUP120==
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| [[3f7f]], [[3h7n]], [[3hxr]] – yNUP120<br />
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| ==NUP133==
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| [[1xks]] – hNUP133 NTD<br />
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| [[3kfo]] – yNUP133 CTD <br />
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| ==NUP145==
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| [[3bg0]], [[3bg1]] – hNUP145+Sec13-related protein<br />
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| [[3kep]], [[3kes]] – yNUP145 autoproteolytic domain<br />
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| [[3jrp]] - yNUP145+protein Sec13<br />
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| ==NUP153==
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| [[3gj3]], [[3gj4]], [[3gj5]], [[3gj6]], [[3gj7]], [[3gj8]], [[3ch5]] – hNUP153+RAN<br />
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| [[2ebq]], [[2ebr]], [[2ebv]], [[2gqe]] - hNUP153 RANBD – NMR<br />
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| [[2k0c]] – rNUP153 RANBD – NMR<br />
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| ==NUP159==
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| [[1xip]] – yNUP159 NTD<br />
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| [[3rrm]] – yNUP159 residues 2-387 + NUP Gle1 + IP6 + ADP<br />
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| ==NUP170==
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| [[3i5p]], [[3i5q]] – yNUP170<br />
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| ==NUP192==
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| [[4ifq]] – yNUP192<br />
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| ==NUP214==
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| [[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br />
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| [[2oit]] – hNUP214 NTD<br />
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| ==NUP358==
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| [[1z5s]] – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN CTD<br />
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| [[1xke]] - hNUP358 RANBD - NMR<br />
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| ==NUP1P==
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| [[2bpt]] – yNUP1P+importin β subunit<br />
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| ==NUP2P==
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| [[1un0]] – yNUP2P NTD+importrin α subunit<br />
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| ==NUP-NSP1==
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| [[1o6o]] – yNUP-NSP1 residues 497-608+importrin β subunit<br />
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| ==NUP-CDC31==
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| [[2doq]], [[2gv5]] – yNUP-CDC31+SFI1P<br />
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| [[3fwb]], [[3fwc]] - yNUP-CDC31+SAC3<br />
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| ==NUP Gle1==
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| [[3peu]], [[3pev]], [[3rrn]]– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6
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| [[2rfo]], [[2qx5]] – yNic96<br />
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| [[1gyb]] – NUP+yNTF2<br />
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| | == References == |
| | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |