Nucleoporin: Difference between revisions

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[[Image:1xip.png|left|200px|thumb|Crystal structure of the N-terminal domain of yeast Nucleoporin NUP159, [[1xip]]]]
<StructureSection load='' size='350' side='right' caption='Yeast nucleoporin NUP159 N-terminal domain (PDB entry [[1xip]])' scene='Nucleoporin/Cv/1'>
{{STRUCTURE_1xip|  PDB=1xip  | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }}
== Function ==
[[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope.  They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD). The images at the left and at the right correspond to one representative Nucleoporin structure, ''i.e.'' crystal structure of yeast Nucleoporin NUP159 from ''Saccharomyces cerevisiae'' ([[1xip]]),
[[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope.  They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)<ref>PMID:9159086</ref>. <br />
*'''NUP1P''' is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture<ref>PMID:8045927</ref>. <br />
*'''NUP2P''' is a yeast nucleoprotein required for bidirectional transport of importin α<ref>PMID:11046143</ref>. <br />
*'''NUP Gle1''' is a yeast and human nucleoprotein required mRNA export. <br />
 
== Disease ==
NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies.  NUP88 is over expressed in ovarian tumors.  NUP214 is the functional receptor of adenovirus 2 nucleocapsids<ref>PMID:14693424</ref>.


{{TOC limit|limit=2}}
== 3D Structures of Nucleoporin ==
== 3D Structures of Nucleoporin ==
[[Nucleoporin 3D structures]]


<br />
</StructureSection>
<br />
<br />
[[3n7c]] – NUP2 RANBD – ''Ashbya gossypii''<br />
[[2c1t]] – yNUP2 N-terminal+importrin alpha subunit - yeast<br />
[[1wwh]] – mNUP35 MPPN domain - mouse<br />
[[2ec1]] – hNUP50 RANBD - human<br />
[[2c1m]] – mNUP50 N-terminal+importin <br />
[[2osz]] – rNUP58/45 - rat<br />
[[3jro]], [[3iko]] – yNUP84+NUP145+protein Sec13<br />
[[3f3f]], [[3f3g]], [[3f3p]], [[3ewe]] – yNUP85+Seh1<br />
[[3mmy]] – hNUP98 fragment+mRNA export factor <br />
[[2q5x]], [[2q5y]] – hNUP98 C-terminal<br />
[[1ko6]] – hNUP98 C-terminal<br />
[[3nf5]] – NUP100 C-terminal – ''Candida glabrata''<br />
[[3i4r]], [[3cqc]], [[3cqg]] – hNUP107+NUP133<br />
[[2aiv]] – yNUP116 C-terminal - NMR<br />
[[3f7f]], [[3h7n]], [[3hxr]] – yNUP120<br />
[[1xks]] – hNUP133 N-terminal<br />
[[3kfo]] – yNUP133 C-terminal <br />
[[3bg0]], [[3bg1]] – hNUP145+Sec13-related protein<br />
[[3kep]], [[3kes]] – yNUP145 autoproteolytic domain<br />
[[3jrp]] - yNUP145+protein Sec13<br />
[[3gj3]], [[3gj4]], [[3gj5]], [[3gj6]], [[3gj7]], [[3gj8]], [[3ch5]] – hNUP153+RAN<br />
[[2ebq]], [[2ebr]], [[2ebv]], [[2gqe]] - hNUP153 RANBD – NMR<br />
[[2k0c]] – rNUP153 RANBD – NMR<br />
[[1xip]] – yNUP159 N-terminal<br />
[[3i5p]], [[3i5q]] – yNUP170<br />
[[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br />
[[2oit]] – hNUP214 N-terminal<br />
[[1z5s]] – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN C-terminal<br />
[[1xke]] - hNUP358 RANBD - NMR<br />
[[2bpt]] – yNUP1P+importin β subunit<br />
[[1un0]] – yNUP2P N-terminal+importrin α subunit<br />
[[1o6o]] – yNUP-NSP1 residues 497-608+importrin β subunit<br />
[[2doq]], [[2gv5]] – yNUP-CDC31+SFI1P<br />
[[3fwb]], [[3fwc]] - yNUP-CDC31+SAC3<br />
[[2rfo]], [[2qx5]] – yNic96<br />
[[1gyb]] – NUP+yNTF2<br />
 


== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 13:08, 11 November 2019

Function

Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)[1].

  • NUP1P is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture[2].
  • NUP2P is a yeast nucleoprotein required for bidirectional transport of importin α[3].
  • NUP Gle1 is a yeast and human nucleoprotein required mRNA export.

Disease

NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids[4].

3D Structures of Nucleoporin

Nucleoporin 3D structures


Yeast nucleoporin NUP159 N-terminal domain (PDB entry 1xip)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Doye V, Hurt E. From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol. 1997 Jun;9(3):401-11. PMID:9159086
  2. ↑ Belanger KD, Kenna MA, Wei S, Davis LI. Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p. J Cell Biol. 1994 Aug;126(3):619-30. PMID:8045927
  3. ↑ Solsbacher J, Maurer P, Vogel F, Schlenstedt G. Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Mol Cell Biol. 2000 Nov;20(22):8468-79. PMID:11046143
  4. ↑ Cronshaw JM, Matunis MJ. The nuclear pore complex: disease associations and functional correlations. Trends Endocrinol Metab. 2004 Jan-Feb;15(1):34-9. PMID:14693424

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