Neurexin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, David Canner, Michal Harel, Joel L. Sussman

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-{{STRUCTURE_3bod|  PDB=3bod  | SIZE=400| SCENE= |right|CAPTION=Mouse neurexin 1α LNS domain with Ca+2 ion ([[3bod]]) }}
+<StructureSection load='' size='350' side='right' caption='Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry [[2xb6]])' scene='42/424006/Cv/2'>
+__TOC__
+== Function ==
+[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons.  The NRXN family contains 4 members which are numbered 1 to 4<ref>PMID:12796785</ref>.  The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6.
-[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons.  The NRXN family contains 4 members which are numbered 1 to 4.  The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. See [[Neurodevelopmental Disorders]].
+See: [[Neurodevelopmental Disorders]]<br />
+[[Neuroligin-Neurexin Interaction]]
-For Structural Analysis of Neurexin, See: [[Neuroligin-Neurexin Interaction]]
+== Relevance ==
+NRXN sequence variants may contribute to autism spectrum disorder and other cognitive diseases<ref>PMID:18179900</ref>.
+== Structural highlights ==
+The <scene name='42/424006/Cv/7'>surface interaction between NRXN and neuroligin</scene> is mediated by a <scene name='42/424006/Cv/8'>Ca+2 ion</scene><ref>PMID:20543817</ref>. Water molecules are shown as red spheres.
+</StructureSection>
 == 3D Structures of Neurexin ==
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 *Neurexin
+**[[5z8y]] – hNRXN-1b + LRRTM2 – human<br />
 **[[3mw2]] – mNRXN-1α LNS domain+splice insert 4 – mouse<br />
-**[[3bod]], [[3bop]] -  mNRXN-1α LNS domain<br />
+**[[3bod]], [[3bop]] -  mβNRXN-1 residues 1132-1246 + mb-NRXN-2 residues 1277-1334<br />
+**[[3mw4]] -  mβNRXN-3 residues 854-1027<br />
+**[[6pnp]], [[6pnq]] - mNRXN-1 LNS2 domain + neurexophilin-1<br />
 **[[3mw3]], [[2r1b]] - rNRXN-1α LNS domain+splice insert 4 – rat<br />
 **[[2r16]] - rNRXN-1α LNS domain+Ca<br />
 **[[1c4r]] -  rNRXN-1α LNS domain<br />
-**[[3mw4]] -  mNRXN-1α LNS domain<br />
+**[[2r1d]] - rNRXN-1β LNS/LG domain<br />
 **[[2h0b]] -  bNRXN-1α LNS2 domain – bovine<br />
+**[[6cw1]] - bNRXN-1 LNS2-LNS3 domains<br />
 **[[3asi]] - bNRXN-1α LNS5-EGF3-LNS6 domains<br />
 **[[3poy]] - bNRXN-1α LNS2-LNS6 domains (mutant)<br />
 **[[3qcw]], [[3r05]] - bNRXN-1α LNS1-LNS6 domains (mutant)<br />
-**[[2r1d]] - rNRXN-1β LNS/LG domain
 *NRXN+Neuroligin
@@ Line 31: / Line 44: @@
 **[[3vkf]] - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain
 }}
+== References ==
+<references/>
 [[Category:Topic Page]]