Matriptase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='4isn' size='340' side='right' caption='Structure of human matriptase catalytic domain (grey) complex with Kunitz-type protease inhibitor (green) and glutathione (PDB code [[4isn]]). ' scene=''>
+<StructureSection load='1eax' size='350' side='right' caption='Structure of human matriptase catalytic domain complex with benzamidine and sulfate (PDB code [[1eax]]). ' scene='59/595760/Cv/1'>
 == Function ==
-'''Matriptase''' or '''suppressor of tumorigenicity 14 protein''' (ST14) is an epithelial-derived, membrane multi-domain serine protease.  ST14 cleaves and activates hepatocyte frowth factor/scatter factor and urokinase plasminogen.  Benzamidine is an inhibitor of ST14.  ST14 catalytic domain contains residues 615-855.
+'''Matriptase''' or '''suppressor of tumorigenicity 14 protein''' (ST14) is an epithelial-derived, membrane multi-domain serine protease.  ST14 cleaves and activates hepatocyte growth factor/scatter factor and urokinase plasminogen.  Benzamidine is an inhibitor of ST14.  ST14 catalytic domain contains residues 615-855<ref>PMID:16838070</ref>.
-== Disease ==
 == Relevance ==
-ST14 is a target for anti-cancer therapy.
+ST14 has a role in ovarian cancer and is a target for anti-cancer therapy<ref>PMID:12779007</ref>.  Inflammation-associated reactive oxygen species and tissue acidity enhance ST14 activation in some skin diseases<ref>PMID:21123732</ref>.
 == Structural highlights ==
+ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>.  The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres.
 == 3D Structures of matriptase ==
+[[Matriptase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-===matriptase===
-[[4is5]] – hST14 catalytic domain - human<br />
-===Matriptase complex with small molecule inhibitor===
-[[1eax]] – hST14 catalytic domain + benzamidine <br />
-[[3p8g]] – hST14 residues 182-422 (mutant) + benzamidine <br />
-[[2gv6]] – hST14 catalytic domain + benzamidine derivative<br />
-[[4o97]], [[4o9v]] – hST14 catalytic domain + benzamidine derivative + tetrapeptide<br />
-[[3ncl]] – hST14 catalytic domain (mutant) + benzamidine derivative<br />
-[[2gv7]], [[4jz1]], [[4jzi]], [[4jyt]] – hST14 catalytic domain + inhibitor<br />
-===Matriptase complex with polypeptide inhibitor===
-[[1eaw]] – hST14 catalytic domain + BPTI<br />
-[[3bn9]] – hST14 catalytic domain + antibody<br />
-[[3nps]], [[3so3]] – hST14 catalytic domain (mutant) + antibody<br />
-[[3p8f]] – hST14 residues 182-422 (mutant) + trypsin inhibitor peptide <br />
-[[4isl]], [[4isn]], [[4iso]] – hST14 catalytic domain (mutant) + Kunitz-type protease inhibitor <br />
 == References ==