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| <StructureSection load='1x2r' size='450' side='right' caption='Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code [[1x2r]])' scene='70/706701/Cv/1'> | | <StructureSection load='' size='450' side='right' caption='Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code [[1x2r]])' scene='70/706701/Cv/1'> |
| == Function == | | == Function == |
| '''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. <scene name='70/706701/Cv/2'>Six to eight such blades form a circular β-propeller domain</scene>. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br /> | | '''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. <scene name='70/706701/Cv/6'>Six to eight such blades form a circular β-propeller domain</scene>. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>.<br /> |
| *'''KLHL1''' may play a role in organizing the actin cytoskeleton in brain cells.<br />
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| *'''KLHL2''' '''KLHL11''' is a component of the cullin-RING based E3 ubiquitin-protein ligase system.<br /> | | *'''KLHL2''' '''KLHL11''' is a component of the cullin-RING based E3 ubiquitin-protein ligase system.<br /> |
| *'''KLHL3''' and '''KLHL7''' '''KLHL10''' are substrate-specific adapters of the cullin-RING based E3 ubiquitin-protein ligase system.<br /> | | *'''KLHL3''' and '''KLHL7''' '''KLHL10''' are substrate-specific adapters of the cullin-RING based E3 ubiquitin-protein ligase system.<br /> |
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| == Structural highlights == | | == Structural highlights == |
| The <scene name='70/706701/Cv/5'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/3'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres. | | The <scene name='70/706701/Cv/7'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/8'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres. |
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| </StructureSection>
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| == 3D Structures of Kelch-like protein == | | == 3D Structures of Kelch-like protein == |
| | [[Kelch-like protein 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Kelch-like protein 1
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| **[[4xmb]] – hKLHL1 Kelch domain + NRF2 activator - human <br />
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| **[[5cgj]] – mKLHL1 Kelch domain + NRF2 activator - mouse <br />
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| *Kelch-like protein 2
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| **[[2xn4]] – hKLHL2 Kelch domain <br />
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| *Kelch-like protein 3
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| **[[4chb]], [[4ch9]], [[5nkp]] – hKLHL3 Kelch domain + serine/threonine protein kinas WNK4 peptide <br />
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| **[[4hxi]] – hKLHL3 BTB-BACK domain (mutant) + cullin-3 N terminal <br />
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| *Kelch-like protein 4
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| **[[2eqx]] – hKLHL4 BACK domain - NMR <br />
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| *Kelch-like protein 5
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| **[[4asc]] – hKLHL5 Kelch domain <br />
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| *Kelch-like protein 7
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| **[[3ii7]] – hKLHL7 Kelch domain <br />
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| *Kelch-like protein 10
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| **[[2woz]] – KLHL10 Kelch domain - rat <br />
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| *Kelch-like protein 11
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| **[[3i3n]] – hKLHL11 BTB-BACK domain <br />
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| **[[4ap2]], [[4apf]] – hKLHL11 BTB-BACK domain + cullin-3 N terminal <br />
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| *Kelch-like protein 12
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| **[[2vpj]] – hKLHL12 Kelch domain <br />
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| *Kelch-like protein 16 (gigaxonin)
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| **[[3hve]] – hKLHL16 <br />
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| **[[2ppi]] – hKLHL16 BTB domain <br />
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| *Kelch-like protein 19 (kelch-like ECH-associated protein 1; Keap1)
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| **[[1u6d]], [[1zgk]], [[4ifj]] – hKeap1 Kelch domain <br />
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| **[[3zgd]] – hKeap1 Kelch domain (mutant) <br />
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| **[[4cxi]], [[4cxj]] – hKeap1 BTB domain (mutant) <br />
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| **[[1x2j]] – mKeap1 Kelch domain <br />
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| *Keap1 complex with peptide
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| **[[1x2r]] – mKeap1 Kelch domain + NRF2 Neh2 peptide <br />
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| **[[2z32]] – mKeap1 Kelch domain + prothymosin a peptide <br />
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| **[[3ade]], [[3wdz]] – mKeap1 Kelch domain + sequestosome-1 peptide <br />
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| **[[2dyh]] – mKeap1 Kelch domain + NRF2 residues 22-36 <br />
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| **[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br />
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| **[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />
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| **[[5nlb]] – hKeap1 BTB+ 3-BOX domains + CUL-3 <br />
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| **[[5f72]] – hKLHL1 Kelch domain + antibody <br />
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| **[[5x54]] – hKLHL1 Kelch domain + tetrapeptide <br />
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| *Keap1 complex with small molecule
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| **[[3vng]], [[3vnh]] – hKeap1 Kelch domain + oxadiazole derivative <br />
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| **[[4ifn]] – hKeap1 Kelch domain + quinoline derivative <br />
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| **[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />
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| **[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor <br />
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| **[[4iqk]], [[4n1b]] – hKeap1 Kelch domain (mutant) + inhibitor <br />
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| **[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />
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| **[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| | [[Category:Topic Page]] |