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<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions  (PDB entry [[1zoo]])' scene=''>
<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions  (PDB entry [[1zoo]])' scene='51/516472/Cv/1'>
== Function ==   
== Function ==   
'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix.  They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>.  IGs contain α and β chain.  IG subunits span the cell membrane.  Both subunits bind divalent cations some of which bind the ligands which interact with IG.  Some IGs contain an insertion domain named I domain.  For more details see [[Molecular Playground/IntegrinBeta1]].
'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix.  They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>.  IGs contain α and β chain.  IG subunits span the cell membrane.  Both subunits bind divalent cations some of which bind the ligands which interact with IG.  Some IGs contain an insertion domain named I domain.  For more details see [[Molecular Playground/IntegrinBeta1]].
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==Disease ==
==Disease ==
Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy.  Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>.  Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.
Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy.  Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>.  Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.
</StructureSection>


==3D structures of integrin==
== Structural highlights ==
The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.
{{#tree:id=OrganizedByTopic|openlevels=0|


*IG CR3
==3D structures of integrin==
 
[[Integrin 3D structures]]
**[[1ido]] – hIG I domain + Mg – human<br />
</StructureSection>
**[[1jlm]] - hIG I domain + Mn<br />
 
*IG CD11a or IG α-L
 
**[[1lfa]] - hIG I domain + Mn<br />
**[[1zon]] - hIG I domain<br />
**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg<br />
**[[1mq9]] - hIG I domain (mutant) + Mn<br />
**[[1mjn]] - hIG I domain (mutant) + Mg<br />
**[[1mqa]] - hIG I domain (mutant) <br />
**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR<BR />
 
*''IG CD11a complexes''
 
**[[1cqp]] - hIG I domain + lovastatin + Mg<br />
**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg<br />
**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
**[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br />
**[[4ixd]] - hIG I domain + activator + Mg<br />
**[[3f78]] - hIG I domain + anesthetic + Mg<br />
**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
 
*IG CD11b
 
**[[1bho]] - hIG I domain + Mg<br />
**[[1bhq]] - hIG I domain + Cd<br />
**[[1m1u]] - hIG I domain (mutant) + Ca<br />
**[[1n9z]] - hIG I domain (mutant) + Mg<br />
**[[1idn]], [[1na5]] - hIG I domain<br />
**[[1mf7]] - hIG I domain (mutant)
 
*IG CD11c
 
**[[1n3y]] - hIG I domain (mutant)
 
*IG α-1 (CD49a)
 
**[[1ck4]] - rIG I domain – rat<br />
**[[4a0q]] - hIG I domain (mutant) + Mg<br />
**[[2l8s]] - hIG transmembrane domain – NMR<BR />
**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
**[[2m32]] - hIG I domain + collagen peptide<br />
 
*IG α-2 (CD49b)
 
**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
 
*IG α-2b
 
**[[2k1a]] - hIG transmembrane domain – NMR<BR />
 
*IG α-1 β-1 (CD49a-CD49b)
 
**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
**[[1pt6]] - hIG I domain + Mg<br />
 
*IG α-2 (CD49b) β
 
**[[1aox]] - hIG I domain (mutant) + Mg<br />
**[[1s4w]], [[1dpk]] - hIG cytoplasmic domain - NMR<BR />
**[[1dpq]] - hIG cytoplasmic domain (mutant) – NMR<br />
 
*IG α-2b β-3 (CD61)
 
**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
**[[4cak]] – hIG – Cryo-EM<br />
**[[2k9j]], [[2knc]] - hIG transmembrane domain – NMR<BR />
**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
**[[3fc3]] – hIG (mutant) + Mg<br />
**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]] – hIG headpiece + antibody + Mg<br />
**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
 
*IG α-4
**[[4irz]] - hIG + antibody <br />
 
*IG α-4 (CD49d) β-7
 
**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
 
*IG α-5 (CD49e) β-1 (CD29)
 
**[[4wjk]] - hIG headpiece (mutant) + Mg<br />
**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br />
**[[3vi3]] - hIG headpiece + antibody + Mg<br />
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
 
*IG α-5 (CD49e) β-3 (CD61)
 
**[[3ije]] – hIG + Ca<br />
**[[1m1x]] - hIG extracellular domain + Mn<br />
**[[4mmx]], [[4mmy]], [[4mmz]] - hIG extracellular domain + Mn + fibronectin domain 10<br />
**[[4o02]] - hIG extracellular domain + Mn + antibody<br />
**[[1u8c]] – hIG psi domain + Ca<br />
**[[1jv2]] - hIG I domain + platelet membrane glycoprotein IIIA + Ca<br />
**[[1l5g]] - hIG I domain + tripeptide + Mn<br />
 
*IG α-5 β-6
 
**[[4um8]] – hIG headpiece (mutant) + Ni<br />
**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β  3<br />
 
*IG α-L
 
**[[4ixd]] – hIG I domain<br />
**[[2m3e]] – hIG transmembrane domain - NMR<br />
 
*IG α-M
 
**[[3q3g]], [[3qa3]] – hIG + antibody<br />
**[[4m76]] – hIG + complement C3<br />
**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
 
*IG α-X
 
**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
 
*IG α-X β-2 (CD18)
 
**[[3k6s]], [[3k71]], [[3k72]] – hIG + Mg<br />
**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />
 
*IG α-V β-3
 
**[[4g1e]], [[4g1m]] – hIG + Ni<br />
 
*IG β-1D
 
**[[3g9w]] – hIG cytoplasmic tail + talin 2 F2-F3 domain<br />
 
*IG β-2 (CD18)
 
**[[2p26]], [[2p28]] – hIG phe2 + phe3 domains<br />
**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />
 
*IG β-3 (CD61)
 
**[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR />
**[[2rmz]], [[2rn0]] – hIG transmembrane domain – NMR<BR />
**[[2l91]] - hIG transmembrane domain (mutant) – NMR<BR />
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
 
*IG β-4 (CD104)
 
**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain<br />
**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />
**[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1 <br />
**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain
 
*IG β-7
 
**[[2brq]], [[2jf1]] – hIG cytoplasmic tail + filamin rod domain<br />


}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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