Integrin: Difference between revisions

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<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions  (PDB entry [[1zoo]])' scene=''>
<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions  (PDB entry [[1zoo]])' scene='51/516472/Cv/1'>
 
== Function == 
'''Integrins''' (IG) are receptors which mediate the attachment between cells or to extracellular matrix.  They are involved in cellular signaling and cell cycle.  IGs contain α and β chain.  IG subunits span the cell membrane.  Both subunits bind divalent cations some of which bind the ligands which interact with IG.  Some IGs contain an insertion domain named I domain.
'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix.  They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>.  IGs contain α and β chain.  IG subunits span the cell membrane.  Both subunits bind divalent cations some of which bind the ligands which interact with IG.  Some IGs contain an insertion domain named I domain.  For more details see [[Molecular Playground/IntegrinBeta1]].


==3D structures of integrin==
For some details on the interaction of a targeting peptide with integrin see [[Molecular Playground/Targeting Peptide]].


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
==Disease ==
{{#tree:id=OrganizedByTopic|openlevels=0|
Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy.  Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>.  Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.


*IG CR3
== Structural highlights ==
The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.


**[[1ido]] – hIG I domain + Mg – human<br />
<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.
**[[1jlm]] - hIG I domain + Mn<br />


*IG CD11a or IG α-L
==3D structures of integrin==
 
[[Integrin 3D structures]]
**[[1lfa]] - hIG I domain + Mn<br />
</StructureSection>
**[[1zon]] - hIG I domain<br />
**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg<br />
**[[1mq9]] - hIG I domain (mutant) + Mn<br />
**[[1mjn]] - hIG I domain (mutant) + Mg<br />
**[[1mqa]] - hIG I domain (mutant) <br />
**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR<BR />
 
*''IG CD11a complexes''
 
**[[1cqp]] - hIG I domain + lovastatin + Mg<br />
**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg<br />
**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
**[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br />
**[[4ixd]] - hIG I domain + activator + Mg<br />
**[[3f78]] - hIG I domain + anesthetic + Mg<br />
**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
 
*IG CD11b
 
**[[1bho]] - hIG I domain + Mg<br />
**[[1bhq]] - hIG I domain + Cd<br />
**[[1m1u]] - hIG I domain (mutant) + Ca<br />
**[[1n9z]] - hIG I domain (mutant) + Mg<br />
**[[1idn]], [[1na5]] - hIG I domain<br />
**[[1mf7]] - hIG I domain (mutant)
 
*IG CD11c
 
**[[1n3y]] - hIG I domain (mutant)
 
*IG α-1 (CD49a)
 
**[[1ck4]] - rIG I domain – rat<br />
**[[4a0q]] - hIG I domain (mutant) + Mg<br />
**[[2l8s]] - hIG transmembrane domain – NMR<BR />
**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
**[[2m32]] - hIG I domain + collagen peptide<br />
 
*IG α-2 (CD49b)
 
**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
 
*IG α-2b
 
**[[2k1a]] - hIG transmembrane domain – NMR<BR />
 
*IG α-1 β-1 (CD49a-CD49b)
 
**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
**[[1pt6]] - hIG I domain + Mg<br />
 
*IG α-2 (CD49b) β
 
**[[1aox]] - hIG I domain (mutant) + Mg<br />
**[[1s4w]] - hIG cytoplasmic domain]] - NMR<BR />
 
*IG α-2b β-3 (CD61)
 
**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
**[[4cak]] – hIG – Cryo-EM<br />
**[[2k9j]], [[2knc]] - hIG transmembrane domain – NMR<BR />
**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
**[[3fc3]] – hIG (mutant) + Mg<br />
**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]] – hIG headpiece + antibody + Mg<br />
**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
 
*IG α-4
**[[4irz]] - hIG + antibody <br />
 
*IG α-4 (CD49d) β-7
 
**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
 
*IG α-5 (CD49e) β-1 (CD29)
 
**[[3vi3]] - hIG headpiece + antibody + Mg<br />
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
 
*IG α-5 (CD49e) β-3 (CD61)
 
**[[3ije]] – hIG + Ca<br />
**[[1m1x]] - hIG extracellular domain + Mn<br />
**[[1u8c]] – hIG psi domain + Ca<br />
**[[1jv2]] - hIG I domain + platelet membrane glycoprotein IIIA + Ca<br />
**[[1l5g]] - hIG I domain + tripeptide + Mn<br />
 
*IG α-M
 
**[[3q3g]], [[3qa3]] – hIG + antibody<br />
**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
 
*IG α-X
 
**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
 
*IG α-X β-2 (CD18)
 
**[[3k6s]], [[3k71]], [[3k72]] – hIG + Mg<br />
**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />
 
*IG α-V β-3
 
**[[4g1e]], [[4g1m]] – hIG + Ni<br />
 
*IG β-1D
 
**[[3g9w]] – hIG cytoplasmic tail + talin 2 F2-F3 domain<br />
 
*IG β-2 (CD18)
 
**[[2p26]], [[2p28]] – hIG phe2 + phe3 domains<br />
**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />
 
*IG β-3 (CD61)
 
**[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR />
**[[2rmz]], [[2rn0]] – hIG transmembrane domain – NMR<BR />
**[[2l91]] - hIG transmembrane domain (mutant) – NMR<BR />
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
 
*IG β-4 (CD104)


**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]] - hIG fibronectin type III domain<br />
== References ==
**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />
<references/>
**[[3f7p]] - hIG fibronectin type III domain + plectin-1 + Ca<br />
**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 13:25, 29 August 2019

Function

Integrins (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle[1]. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see Molecular Playground/IntegrinBeta1.

For some details on the interaction of a targeting peptide with integrin see Molecular Playground/Targeting Peptide.

Disease

Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis[2]. Defective integrin is involved in periodontal diseases[3].

Structural highlights

The interactions of integrin with ligands are dependent on the presence of divalent ions[4].

. Water molecules shown as red spheres.

3D structures of integrin

Integrin 3D structures

Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry 1zoo)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
  2. ↑ Hillis GS, MacLeod AM. Integrins and disease. Clin Sci (Lond). 1996 Dec;91(6):639-50. PMID:8976799
  3. ↑ Larjava H, Koivisto L, Heino J, Hakkinen L. Integrins in periodontal disease. Exp Cell Res. 2014 Jul 15;325(2):104-10. doi: 10.1016/j.yexcr.2014.03.010. Epub, 2014 Mar 22. PMID:24662197 doi:http://dx.doi.org/10.1016/j.yexcr.2014.03.010
  4. ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914

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Michal Harel, Alexander Berchansky
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