6h7c: Difference between revisions
Jump to navigation
Jump to search
New page: '''Unreleased structure''' The entry 6h7c is ON HOLD Authors: Nguyen, T.X.P., Heine, A., Klebe, G. Description: tRNA guanine transglycosylase H333A mutant apo structure [[Category: Unr... |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
==tRNA guanine transglycosylase H333A mutant apo structure== | |||
<StructureSection load='6h7c' size='340' side='right'caption='[[6h7c]], [[Resolution|resolution]] 1.68Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6h7c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H7C FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l56|4l56]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h7c OCA], [http://pdbe.org/6h7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h7c RCSB], [http://www.ebi.ac.uk/pdbsum/6h7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h7c ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Heine, A]] | |||
[[Category: Klebe, G]] | [[Category: Klebe, G]] | ||
[[Category: Nguyen, T | [[Category: Nguyen, T X.P]] | ||
[[Category: | [[Category: Homodimer]] | ||
[[Category: Mutation]] | |||
[[Category: Ppi]] | |||
[[Category: Tgt]] | |||
[[Category: Transferase]] | |||
Latest revision as of 19:29, 14 August 2019
tRNA guanine transglycosylase H333A mutant apo structuretRNA guanine transglycosylase H333A mutant apo structure
Structural highlights
Function[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] |
| ||||||||||||||||||||