Phenylpyruvate decarboxylase: Difference between revisions
Jump to navigation
Jump to search
Michal Harel (talk | contribs) No edit summary |
No edit summary |
||
| (6 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='2q5o' size='350' side='right' scene='46/468226/Cv/1' caption='Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]]'> | |||
== Function == | == Function == | ||
'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism<ref>PMID:12902239</ref>. PPDC is a thiamine diphosphate (ThDP) (i.e., vitamin B1)-dependent enzyme. | '''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism<ref>PMID:12902239</ref>. PPDC is a thiamine diphosphate (ThDP) (i.e., vitamin B1)-dependent enzyme. | ||
== Structural highlights == | == Structural highlights == | ||
PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>. | PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>. | ||
*<scene name='46/468226/Cv/6'>ThDP cofactor/phenypyruvate substrate binding site</scene>. Water molecules are shown as red spheres. | |||
*<scene name='46/468226/Cv/7'>Mg coordination site</scene>. | |||
</StructureSection> | |||
== 3D Structures of phenylpyruvate decarboxylase == | == 3D Structures of phenylpyruvate decarboxylase == | ||