Phenylpyruvate decarboxylase: Difference between revisions
Michal Harel (talk | contribs) New page: {{STRUCTURE_2q5o| PDB=2q5o | SIZE=400| SCENE= |right|CAPTION=Phenylpyruvate decarboxylase complex with phenylpyruvate and deaza-ThDP, 2q5o }} '''Phenylpyruvate decarboxylase''' (PPD... |
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<StructureSection load='2q5o' size='350' side='right' scene='46/468226/Cv/1' caption='Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion [[2q5o]]'> | |||
'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism. | == Function == | ||
'''Phenylpyruvate decarboxylase''' (PPDC) catalyzes the conversion of phenylpyruvate to phenylacetaldehyde. PPDC participates in phenylalanine and tryptophan metabolism<ref>PMID:12902239</ref>. PPDC is a thiamine diphosphate (ThDP) (i.e., vitamin B1)-dependent enzyme. | |||
== Structural highlights == | |||
PPDC active site contains the ThDP cofactor and the phenypyruvate substrate<ref>PMID:17905741</ref>. | |||
*<scene name='46/468226/Cv/6'>ThDP cofactor/phenypyruvate substrate binding site</scene>. Water molecules are shown as red spheres. | |||
*<scene name='46/468226/Cv/7'>Mg coordination site</scene>. | |||
</StructureSection> | |||
== 3D Structures of phenylpyruvate decarboxylase == | == 3D Structures of phenylpyruvate decarboxylase == | ||
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[[2q5q]] - AbPPDC + deaza-ThDP + phenylvalerate | [[2q5q]] - AbPPDC + deaza-ThDP + phenylvalerate | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||