Neurophysin: Difference between revisions

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New page: <StructureSection load='1npo' size='340' side='right' caption='Neurophysin-2 complex with oxytocin (PDB code 1npo)' scene=''> '''Neurophysins''' are carrier proteins which transport h...
 
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<StructureSection load='' size='350' side='right' caption='Neurophysin-2 (green and cyan) complex with oxytocin (magenta and salmon) (PDB code [[1npo]])' scene='70/706270/Cv/1' pspeed='8'>
== Function ==
'''Neurophysins''' are carrier proteins which transport hormones from the hypothalamus to the posterior pituitary gland<ref>PMID:3147712</ref>. 


<StructureSection load='1npo' size='340' side='right' caption='Neurophysin-2 complex with oxytocin (PDB code [[1npo]])' scene=''>
*'''Neurophysin-1''' transports oxytocin.<br />
'''Neurophysins''' are carrier proteins which transport hormones from the hypothalamus to the posterior pituitary gland.  Neurophysin-1 transports oxytocin and neurophysin-2 transports vasopressin. '''Oxytocin''' is used to start labor and increase its speed. '''Vasopressin''' functions to retain water in the body and to constrict blood vessels.
*'''Neurophysin-2''' transports vasopressin.<br />
 
*'''Oxytocin''' is used to start labor and increase its speed.<br />
== Function ==
*'''Vasopressin''' functions to retain water in the body and to constrict blood vessels.


== Disease ==
== Disease ==
 
Mutations in neurophysin-2 are associated with familial diabetes<ref>PMID:7714110</ref>.
== Relevance ==


== Structural highlights ==
== Structural highlights ==
<scene name='70/706270/Cv/4'>Neurophysin-2/oxytocin interactions</scene>.


</StructureSection>
</StructureSection>
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

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Michal Harel, Alexander Berchansky, Joel L. Sussman