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| <StructureSection load='4ept' size='400' side='right' caption='Structure of human GDP-bound GTPase KRas G12 mutant complex with inhibitor and GDP (PDB entry [[4ept]])' scene='78/781207/Cv/1'> | | <StructureSection load='' size='400' side='right' caption='Structure of human GDP-bound GTPase KRas G12 mutant complex with inhibitor and GDP (PDB entry [[4ept]])' scene='78/781207/Cv/1'> |
| == Function == | | == Function == |
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| == Structural highlights == | | == Structural highlights == |
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| The GDP-bound KRas binds a <scene name='78/781207/Cv/2'>small molecule inhibitor in its binding cleft</scene> following conformational change of the protein<ref>PMID:22566140</ref>. <scene name='78/781207/Cv/6'>GDP binding site</scene>. | | The GDP-bound KRas binds a <scene name='78/781207/Cv/2'>small molecule inhibitor in its binding cleft</scene> following conformational change of the protein<ref>PMID:22566140</ref>. Water molecules are shown as red spheres. |
| </StructureSection> | | *<scene name='78/781207/Cv/9'>Inhibitor binding cleft</scene>. |
| | *<scene name='78/781207/Cv/7'>GDP binding site</scene>. |
| | *<scene name='78/781207/Cv/8'>Mg coordination site</scene>. |
| | *<scene name='78/781207/Cv/10'>GDP/Mg binding cleft</scene>. |
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| == 3D Structures of GTPase KRas == | | == 3D Structures of GTPase KRas == |
| | [[GTPase KRas 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *GTPase KRas
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| **[[5uk9]] – hKRas + GCP + GDP – human <br />
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| **[[5vq2]] – hKRas + GTP <br />
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| **[[5w22]], [[4obe]], [[4lpk]], [[5vq8]] – hKRas + GDP <br />
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| **[[3gft]] – hKRas (mutant) + GTP analog <br />
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| **[[4l8g]], [[4ldj]], [[4ql3]], [[4tq9]], [[4tqa]], [[6asa]], [[6ase]], [[5whd]], [[5uqw]], [[5us4]], [[5vp7]], [[5vq0]], [[5vq1]], [[4wa7]], [[4lrw]] – hKRas (mutant) + GDP <br />
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| **[[5vpi]], [[5vpz]], [[5vq6]] – hKRas (mutant) + GTP <br />
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| **[[5usj]], [[5vpy]] – hKRas (mutant) + GNP <br />
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| **[[6bp1]], [[4dsn]] – hKRas (mutant) + GCP <br />
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| **[[4dso]] – hKRas (mutant) + inhibitor + GSP <br />
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| **[[4dst]] – hKRas (mutant) + inhibitor + GCP <br />
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| **[[5kyk]] – hKRas + inhibitor <br />
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| **[[4nmm]] – hKRas (mutant) + inhibitor <br />
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| **[[5v9o]], [[5f2e]], [[5v9u]], [[4dsu]], [[4luc]], [[4lv6]], [[4lyf]], [[4lyh]], [[4lyj]], [[4m1o]], [[4m1s]], [[4m1t]], [[4m1w]], [[4m1y]], [[4m21]], [[4m22]], [[4epr]], [[4ept]], [[4epv]], [[4epw]], [[4epx]], [[4epy]], [[4q02]], [[4q03]], [[5vbm]], [[5v6s]], [[5v6v]], [[6ark]], [[5xco]] – hKRas (mutant) + GDP + inhibitor <br />
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| **[[5vbz]] – hKRas (mutant) + GNP + inhibitor <br />
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| **[[5v71]], [[5v9l]] – hKRas (mutant) + GDP + quinazoline inhibitor <br />
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| *GTPase KRas complex with protein
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| **[[5wha]], [[5whb]] – hKRas (mutant) + miniprotein + GDP <br />
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| **[[5wpl]], [[5whe]], [[5wpm]], [[5wlb]] – hKRas (mutant) + miniprotein + GNP <br />
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| **[[5o2s]], [[5mlb]] – hKRas + darpin K27 + GDP <br />
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| **[[5o2s]], [[5tb5]] – hKRas + GMP-PDE d + farnesyl + GDP <br />
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| **[[5o2t]], [[5mla]] – hKRas + darpin 55 + GSP <br />
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| **[[5o2s]] – hKRas + R11.1.6 + GNP <br />
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| **[[5ufq]] – hKRas (mutant) + R11.1.6 + GNP <br />
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| **[[2msc]], [[2msd]] – hKRas + apolipoprotein + GDP - NMR<br />
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| **[[2mse]] – hKRas + apolipoprotein + A-Raf + GDP - NMR<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |