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| <StructureSection load='1bmb' size='350' side='right' caption='Structure of human Grb2 SH2 domain (green) complex with phosphotyrosyl polypeptide (magenta) (PDB entry [[1bmb]])' scene='51/516448/Cv/1'> | | <StructureSection load='' size='350' side='right' caption='Structure of human Grb2 SH2 domain (green) complex with phosphotyrosyl polypeptide (magenta) (PDB entry [[1bmb]])' scene='51/516448/Cv/1'> |
| == Function == | | == Function == |
| '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | | '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> |
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| == Structural highlights == | | == Structural highlights == |
| Human GRB2 residue <scene name='51/516448/Cv/4'>Trp121 forces the phosphotyrosyl containing ligand</scene> into a turn conformation. <scene name='51/516448/Cv/3'>Phosphotyrosine binding</scene> <ref>PMID:10090780</ref>. | | Human GRB2 residue <scene name='51/516448/Cv/5'>Trp121 forces the phosphotyrosyl containing ligand</scene> into a turn conformation. Water molecules are shown as red spheres. <scene name='51/516448/Cv/6'>Phosphotyrosine binding</scene> <ref>PMID:10090780</ref>. |
| </StructureSection>
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| ==3D structures of growth factor receptor-bound proteins== | | ==3D structures of growth factor receptor-bound proteins== |
| | [[Growth factor receptor-bound proteins 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *GRB2
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| **[[1gri]], [[2h46]] – hGRB2 – human <br />
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| *''GRB2 C terminal SH3 domain''
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| **[[1gfc]], [[1gfd]] – hGRB2 C terminal SH3 domain - NMR<br />
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| **[[2vvk]], [[2vwf]], [[2w0z]] – hGRB2 C terminal SH3 domain <br />
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| **[[1io6]] – hGRB2 C terminal SH3 domain + ligand peptide - NMR<br />
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| **[[1gcq]] – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain<br />
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| *''GRB2 N terminal SH3 domain''
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| **[[1gbr]], [[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]] – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR<br />
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| **[[1aze]] – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR<br />
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| *''GRB2 SH2 domain''
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| **[[1jyu]] – hGRB2 SH2 domain <br />
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| **[[1ghu]] – hGRB2 SH2 domain (mutant) - NMR<br />
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| **[[1fhs]] – hGRB2 SH2 domain - NMR<br />
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| **[[1x0n]] – hGRB2 SH2 domain + inhibitor - NMR<br />
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| **[[2huw]] – hGRB2 SH2 domain + cyclopropane derivative<br />
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| **[[1cj1]] – hGRB2 SH2 domain + phosphor-Tyr derivative<br />
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| **[[2aoa]], [[2aob]] – hGRB2 SH2 domain + peptide mimetic<br />
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| **[[1tze]], [[1bmb]], [[1bm2]], [[1zfp]], [[1fyr]], [[1jyq]], [[1jyr]], [[2h5k]], [[3c7i]], [[3imd]], [[3imj]], [[3in7]], [[3in8]], [[3kfj]], [[3n8m]], [[3n7y]], [[3n84]], [[3mxc]], [[3mxy]], [[3ov1]], [[3ove]], [[3s8l]], [[3s8n]], [[3s8o]], [[1zfp]], [[4p9v]], [[4p9z]] – hGRB2 SH2 domain + phosphor-Tyr peptide<br />
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| **[[5cdw]] – hGRB2 SH2 domain (mutant) + phosphor-Tyr peptide <br />
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| **[[1qg1]] – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR<br />
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| **[[3wa4]] - hGRB2 SH2 domain + CD28 peptide <br />
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| *GRB4
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| **[[4e6r]] – hGRB4 C terminal SH3 domain <br />
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| *GRB7
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| **[[2qms]], [[4wwq]] – hGRB7 SH2 domain <br />
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| **[[4x6s]], [[5d0j]], [[5eel]], [[5eeq]] – hGRB7 SH2 domain + phosphor-Tyr peptide <br />
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| **[[1mw4]], [[2l4k]] – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR<br />
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| **[[3pqz]] – hGRB7 SH2 domain + cyclic peptide <br />
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| **[[1wgr]] – hGRB7 RA domain - NMR<br />
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| *GRB10
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| **[[1nrv]] – hGRB10 SH2 domain <br />
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| **[[3m7f]] – hGRB10 SH2 domain + NEDD4 C2 domain<br />
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| **[[3hk0]] – hGRB10 RA and PH domains <br />
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| *GRB14
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| **[[2aug]] – hGRB14 SH2 domain <br />
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| **[[2auh]] – hGRB14 BPS domain + insulin receptor kinase domain<br />
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| **[[4k81]] – hGRB14 RA and PH domains + GTPase Hras<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |