Geranylgeranyl pyrophosphate synthase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='' size='350' side='right' scene='54/540181/Cv/1' caption='Geranylgeranyl pyrophosphate synthase dimer complex with GGPP and Mg+2 (green)  [[2z4v]]'>
-[[Image:2z4v.png|left|200px|thumb|Crystal Structure of geranylgeranyl pyrophosphate synthase complex with GGPP and Mg+2  [[2z4v]]]]
-{{STRUCTURE_2z4v|  PDB=2z4v  | SIZE=350| SCENE= |right|CAPTION=Geranylgeranyl pyrophosphate synthase complex with GGPP and Mg+2   [[2z4v]] }}
+== Function ==
+'''Geranylgeranyl pyrophosphate synthase''' (GGPPS) catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate and isopentenyl diphosphate.  GGPPS is involved in the addition of hydrophobic molecules to proteins and in the regulation of a nuclear hormone receptor<ref>PMID:2730002</ref>.
+== Relevance ==
+GGPPS inhibitors are studied as therapeutical targets since geranylgeranylation is a post-translational modification of several proteins involved in human disease<ref>PMID:22048229</ref>.
+== Structural highlights ==
+<scene name='54/540181/Cv/5'>GGPP - the product of GGPPS catalysis interacts with Mg+2 ions in the active site</scene><ref>PMID:18800762</ref>. Water molecules shown as red spheres.
+== 3D Structures of geranylgeranyl pyrophosphate synthase==
+[[Geranylgeranyl pyrophosphate synthase 3D structures]]
+</StructureSection>
+== References ==
+<references/>
+[[Category:Topic Page]]
-'''Geranylgeranyl pyrophosphate synthase''' (GGPPS) catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate and isopentenyl diphosphate.  GGPPS is involved in the addition of hydrophobic molecules to proteins and in the regulation of a nuclear hormone receptor.
-== 3D Structures of geranylgeranyl pyrophosphate synthase==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[2dh4]] – yGGPPS + Mg - yeast<br />
-[[2e8t]] – yGGPPS + Mg + isopentenyl pyrophosphate + farnesyl thiopyrophosphate<br />
-[[2e8u]], [[2e8w]] – yGGPPS + Mg + isopentenyl pyrophosphate <br />
-[[2e8v]] – yGGPPS + GGPP<br />
-[[2z4v]] – yGGPPS + GGPP + Mg<br />
-[[2e8x]] – yGGPPS + GPP + Mg<br />
-[[2e90]] – yGGPPS + Mg + PP + farnesyl pyrophosphate<br />
-[[2e91]], [[2e92]], [[2e93]], [[2e94]], [[2e95]], [[2z7h]], [[2z4w]], [[2z4x]], [[2z4y]], [[2z4z]], [[2z50]], [[2z52]], [[2z78]], [[2z7i]], [[2zeu]] – yGGPPS + Mg + inhibitor<br />
-[[2zev]] – yGGPPS + Mg + isopentenyl pyrophosphate + inhibitor<br />
-[[2q80]] – GGPPS + GGPP + Mg - human<br />