Formate dehydrogenase: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

@@ Line 2: / Line 2: @@
 '''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate.  The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome.  The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>.
-*<scene name='49/491980/Cv/6'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres.
+*<scene name='49/491980/Cv/8'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres.
-*<scene name='49/491980/Cv/7'>Azide ion binding site</scene>.
+*<scene name='49/491980/Cv/9'>Azide ion binding site</scene>.
-</StructureSection>
 ==3D structure of formate dehydrogenase==
+[[Formate dehydrogenase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*NAD-dependent FDH
-**[[2nac]], [[2go1]] – PsFDH – ''Pseudomonas''<BR />
-**[[2fss]], [[5dna]] – CbFDH – ''Candida boidinii''<BR />
-**[[2j6i]] – CbFDH C terminal (mutant) <BR />
-**[[3fn4]] - MoFDH – ''Moraxella''<BR />
-**[[3naq]], [[3jtm]] – ArFDH – ''Arabidopsis thaliana''<BR />
-**[[2nad]] – PsFDH + NAD<BR />
-**[[2gug]] – PsFDH + formate<BR />
-**[[2gsd]] – MoFDH + NAD + N3<BR />
-**[[3n7u]] - ArFDH + NAD + N3<BR />
-**[[3wr5]] – FDH + NAD – ''Thiobacillus''<br />
-**[[4xyg]] – GmFDH – ''Granulicella mallensis''<br />
-**[[4xyb]] – GmFDH + NADP <br />
-**[[4xye]] – GmFDH + NAD<br />
-*Mo-dependent FDH
-**[[1aa6]], [[1fdo]], [[2iv2]] – EcFDH-H + Fe4S4 + MGD – ''Escherichia coli''<BR />
-**[[1fdi]] - EcFDH-H + Fe4S4 + NO2 + MGD<BR />
-**[[1kqf]] - EcFDH-N + Fe4S4 + protoporphyrin + MGD<BR />
-**[[1kqg]] - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD<BR />
-**[[1h0h]] - FDH + Fe4S4 +MGD – ''Desulfovibrio gigas''
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]